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Zymeworks Inc. (ZYME) Fundamental Analysis & AI Grade 2026

ZYME Nasdaq Pharmaceutical Preparations DE CIK: 0001937653
Update Pending • Analysis: May 9, 2026 • SEC Data: 2026-03-31
Combined AI Grade
C
68% Confidence
N/A
C
68% Conf
Pending
Analysis scheduled

📊 ZYME Key Takeaways

Revenue: $2.4M
Net Margin: -1,834.0%
Free Cash Flow: $-45.9M
Current Ratio: 10.82x
Debt/Equity: 0.00x
EPS: $-0.59
AI Grade: C with 68% confidence
Zymeworks Inc. (ZYME) receives a C fundamental grade with 68% confidence from our AI analysis based on SEC 10-K filings. With revenue of $2.4M, net profit margin of -1,834.0%, and return on equity (ROE) of -27.0%, Zymeworks Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ZYME stock analysis for 2026.

Is Zymeworks Inc. (ZYME) a Good Investment?

Claude

Early-stage pharmaceutical company with a fortress balance sheet ($244.3M cash, zero debt) but extreme cash burn (-$45.7M annually) and minimal revenue ($2.4M); while balance sheet strength provides multi-year runway and 38.9% revenue growth shows improvement, the company remains far from profitability with -1834% net margins and no clear path to sustainable operations without major clinical breakthroughs.

Zymeworks Inc. Key Strengths (ZYME)

Claude
  • + Fortress balance sheet with $244.3M cash and zero long-term debt, providing substantial financial flexibility and ~5+ year runway at current burn rate
  • + Excellent liquidity position (10.82x current ratio) mitigates near-term financial distress risk despite ongoing losses
  • + Revenue growth of 38.9% YoY and improving unit economics (EPS loss reduced 33.3% YoY) suggest early commercialization momentum

ZYME Stock Risks: Zymeworks Inc. Investment Risks

Claude
  • ! Massive operating losses (-$47.1M) on minimal revenue ($2.4M) with -1834% net margin; business model is fundamentally unprofitable at current scale
  • ! Significant operating cash burn rate (-$45.7M annually) is unsustainable without achievement of major pharmaceutical milestone or partnership event
  • ! Pharmaceutical/biotech regulatory risk with uncertain pipeline success; no visibility into clinical trial outcomes or commercialization timeline from financials alone

Key Metrics to Watch

Claude
  • * Quarterly operating cash burn trend and timeline to cash flow breakeven
  • * Revenue trajectory and composition (recurring vs. milestone/license revenue)
  • * Pipeline clinical trial results, regulatory approvals, and partnership announcements
  • * R&D and G&A expense trends relative to revenue growth
  • * Cash balance depletion rate and potential for equity raise dilution

Zymeworks Inc. (ZYME) Financial Metrics & Key Ratios

Revenue
$2.4M
Net Income
$-44.2M
EPS (Diluted)
$-0.59
Free Cash Flow
$-45.9M
Total Assets
$478.2M
Cash Position
$244.3M

💡 AI Analyst Insight

Strong liquidity with a 10.82x current ratio provides a solid financial cushion.

ZYME Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -1,956.7%
Net Margin -1,834.0%
ROE -27.0%
ROA -9.2%
FCF Margin -1,907.6%

ZYME vs Healthcare Sector: How Zymeworks Inc. Compares

How Zymeworks Inc. compares to Healthcare sector averages

Net Margin
ZYME -1,834.0%
vs
Sector Avg 12.0%
ZYME Sector
ROE
ZYME -27.0%
vs
Sector Avg 15.0%
ZYME Sector
Current Ratio
ZYME 10.8x
vs
Sector Avg 2.0x
ZYME Sector
Debt/Equity
ZYME 0.0x
vs
Sector Avg 0.6x
ZYME Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Zymeworks Inc. Stock Overvalued? ZYME Valuation Analysis 2026

Based on fundamental analysis, Zymeworks Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-27.0%
Sector avg: 15%
Net Profit Margin
-1,834.0%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Zymeworks Inc. Balance Sheet: ZYME Debt, Cash & Liquidity

Current Ratio
10.82x
Quick Ratio
10.82x
Debt/Equity
0.00x
Debt/Assets
65.8%
Interest Coverage
N/A
Long-term Debt
N/A

ZYME Revenue & Earnings Growth: 5-Year Financial Trend

ZYME 5-year financial data: Year 2022: Revenue $412.5M, Net Income -$180.6M, EPS $-3.58. Year 2023: Revenue $412.5M, Net Income -$211.8M, EPS $-4.61. Year 2024: Revenue $412.5M, Net Income $124.3M, EPS $1.90. Year 2025: Revenue $106.0M, Net Income -$118.7M, EPS $-1.72.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Zymeworks Inc.'s revenue has declined by 74% over the 5-year period, indicating business contraction. The most recent EPS of $-1.72 indicates the company is currently unprofitable.

ZYME Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-1,907.6%
Free cash flow / Revenue

ZYME Quarterly Earnings & Performance

Quarterly financial performance data for Zymeworks Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $2.4M -$22.6M $-0.30
Q3 2025 $16.0M $2.3M $-0.26
Q2 2025 $19.2M $2.3M $0.03
Q1 2025 $10.0M -$22.6M $-0.30
Q3 2024 $16.0M -$24.4M $-0.39
Q2 2024 $7.0M -$24.4M $-0.49
Q1 2024 $10.0M -$24.4M $-0.37
Q3 2023 $2.6M -$24.4M $-0.41

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Zymeworks Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$45.7M
Cash generated from operations
Stock Buybacks
$76.2M
Shares repurchased (TTM)
Capital Expenditures
$216.0K
Investment in assets
Dividends
None
No dividend program

ZYME SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Zymeworks Inc. (CIK: 0001937653)

📋 Recent SEC Filings

Date Form Document Action
May 15, 2026 4 xslF345X06/ownership.xml View →
May 14, 2026 8-K d110930d8k.htm View →
May 7, 2026 10-Q zyme-20260331.htm View →
May 7, 2026 8-K zyme-20260507.htm View →
Apr 10, 2026 4 xslF345X06/ownership.xml View →

Frequently Asked Questions about ZYME

What is the AI rating for ZYME?

Zymeworks Inc. (ZYME) has an AI grade of C with 68% confidence, based on fundamental analysis of SEC EDGAR filings.

What are ZYME's key strengths?

Claude: Fortress balance sheet with $244.3M cash and zero long-term debt, providing substantial financial flexibility and ~5+ year runway at current burn rate. Excellent liquidity position (10.82x current ratio) mitigates near-term financial distress risk despite ongoing losses.

What are the risks of investing in ZYME?

Claude: Massive operating losses (-$47.1M) on minimal revenue ($2.4M) with -1834% net margin; business model is fundamentally unprofitable at current scale. Significant operating cash burn rate (-$45.7M annually) is unsustainable without achievement of major pharmaceutical milestone or partnership event.

What is ZYME's revenue and growth?

Zymeworks Inc. reported revenue of $2.4M.

Does ZYME pay dividends?

Zymeworks Inc. does not currently pay dividends.

Where can I find ZYME SEC filings?

Official SEC filings for Zymeworks Inc. (CIK: 0001937653) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ZYME's EPS?

Zymeworks Inc. has a diluted EPS of $-0.59.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined grade reflects both perspectives for balanced insights.

What is ZYME's fundamental grade?

Based on our AI fundamental analysis in June 2026, Zymeworks Inc. has a C grade with 68% confidence. Review the strengths and risks sections above for full context. This is not investment advice.

Is ZYME stock overvalued or undervalued?

Valuation metrics for ZYME: ROE of -27.0% (sector avg: 15%), net margin of -1,834.0% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

What is ZYME's AI grade for 2026?

Our dual AI analysis gives Zymeworks Inc. a combined C grade for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ZYME's free cash flow?

Zymeworks Inc.'s operating cash flow is $-45.7M, with capital expenditures of $216.0K. FCF margin is -1,907.6%.

How does ZYME compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -1,834.0% (avg: 12%), ROE -27.0% (avg: 15%), current ratio 10.82 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 9, 2026 | Data as of: 2026-03-31 | Powered by Claude AI