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Xilio Therapeutics, Inc. (XLO) Stock Fundamental Analysis & AI Rating 2026

XLO Nasdaq Pharmaceutical Preparations DE CIK: 0001840233
Recently Updated • Analysis: May 16, 2026 • SEC Data: 2026-03-31
Combined AI Rating
HOLD
68% Confidence
N/A
HOLD
68% Conf
Pending
Analysis scheduled

📊 XLO Key Takeaways

Revenue: $12.6M
Net Margin: -75.3%
Free Cash Flow: $-22.9M
Current Ratio: 3.59x
Debt/Equity: 0.00x
EPS: $-0.58
AI Rating: HOLD with 68% confidence
Xilio Therapeutics, Inc. (XLO) receives a HOLD rating with 68% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $12.6M, net profit margin of -75.3%, and return on equity (ROE) of -13.1%, Xilio Therapeutics, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete XLO stock analysis for 2026.

Is Xilio Therapeutics, Inc. (XLO) a Good Investment?

Claude

Xilio Therapeutics demonstrates exceptional revenue growth of 589.9% YoY with a fortress balance sheet of $150.3M cash and zero debt, providing substantial runway for development. However, the company is pre-profitability with deeply negative margins (-111.6% operating) and annual cash burn of $22.3M, requiring significant revenue acceleration or cost discipline to achieve sustainability.

Why Buy Xilio Therapeutics, Inc. Stock? XLO Key Strengths

Claude
  • + Exceptional top-line growth of 589.9% YoY indicating strong market traction and product demand
  • + Fortress balance sheet with $150.3M cash representing 92% of total assets and zero long-term debt, providing 6-7 years of runway at current burn rates
  • + Excellent liquidity position with 3.59x current and quick ratios, eliminating near-term financial distress risk

XLO Stock Risks: Xilio Therapeutics, Inc. Investment Risks

Claude
  • ! Deeply unprofitable with operating margin of -111.6% and net margin of -75.3%, indicating business model not yet economically viable
  • ! Negative free cash flow of -$22.9M annually with ongoing cash burn despite revenue growth, raising concerns about path to profitability
  • ! Small revenue base of $12.6M suggests early commercialization stage; inability to scale revenues faster than burn rate will deplete cash reserves
  • ! Pharmaceutical sector inherent risks including clinical trial failures, regulatory setbacks, and competitive pressures typical for development-stage biotech

Key Metrics to Watch

Claude
  • * Revenue growth trajectory and ability to maintain/exceed 589.9% YoY growth rate
  • * Operating cash flow trend and timeline to reach FCF breakeven
  • * Quarterly cash burn rate and cash balance depletion forecast given current trajectory
  • * Gross margin expansion as revenue scales and manufacturing efficiencies improve
  • * Product pipeline advancement and clinical/regulatory milestones affecting commercialization potential

Xilio Therapeutics, Inc. (XLO) Financial Metrics & Key Ratios

Revenue
$12.6M
Net Income
$-9.5M
EPS (Diluted)
$-0.58
Free Cash Flow
$-22.9M
Total Assets
$163.5M
Cash Position
$150.3M

💡 AI Analyst Insight

Strong liquidity with a 3.59x current ratio provides a solid financial cushion.

XLO Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -111.6%
Net Margin -75.3%
ROE -13.1%
ROA -5.8%
FCF Margin -181.0%

XLO vs Healthcare Sector: How Xilio Therapeutics, Inc. Compares

How Xilio Therapeutics, Inc. compares to Healthcare sector averages

Net Margin
XLO -75.3%
vs
Sector Avg 12.0%
XLO Sector
ROE
XLO -13.1%
vs
Sector Avg 15.0%
XLO Sector
Current Ratio
XLO 3.6x
vs
Sector Avg 2.0x
XLO Sector
Debt/Equity
XLO 0.0x
vs
Sector Avg 0.6x
XLO Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Xilio Therapeutics, Inc. Stock Overvalued? XLO Valuation Analysis 2026

Based on fundamental analysis, Xilio Therapeutics, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-13.1%
Sector avg: 15%
Net Profit Margin
-75.3%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Xilio Therapeutics, Inc. Balance Sheet: XLO Debt, Cash & Liquidity

Current Ratio
3.59x
Quick Ratio
3.59x
Debt/Equity
0.00x
Debt/Assets
55.6%
Interest Coverage
N/A
Long-term Debt
N/A

XLO Revenue & Earnings Growth: 5-Year Financial Trend

XLO 5-year financial data: Year 2024: Revenue $6.3M, Net Income -$76.4M, EPS $-2.78. Year 2025: Revenue $43.8M, Net Income -$58.2M, EPS $-15.24.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Xilio Therapeutics, Inc.'s revenue has grown significantly by 590% over the 5-year period, indicating strong business expansion. The most recent EPS of $-15.24 indicates the company is currently unprofitable.

XLO Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-181.0%
Free cash flow / Revenue

XLO Quarterly Earnings & Performance

Quarterly financial performance data for Xilio Therapeutics, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q1 2026 $2.9M -$9.5M $-0.58
Q3 2025 $2.3M -$14.0M $-0.11
Q2 2025 $2.4M -$13.9M $-0.16
Q1 2025 $2.9M -$13.3M $-0.18
Q3 2024 $2.3M -$14.0M $-0.22
Q2 2024 $2.4M -$13.9M $-0.24

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Xilio Therapeutics, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$22.3M
Cash generated from operations
Capital Expenditures
$556.0K
Investment in assets
Dividends
None
No dividend program

XLO SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Xilio Therapeutics, Inc. (CIK: 0001840233)

📋 Recent SEC Filings

Date Form Document Action
May 12, 2026 10-Q xlo-20260331.htm View →
May 12, 2026 8-K xlo-20260512.htm View →
Apr 28, 2026 DEF 14A xlo-20260428.htm View →
Apr 16, 2026 4 xslF345X06/ownership.xml View →
Apr 16, 2026 8-K xlo-20260416.htm View →

Frequently Asked Questions about XLO

What is the AI rating for XLO?

Xilio Therapeutics, Inc. (XLO) has an AI rating of HOLD with 68% confidence, based on fundamental analysis of SEC EDGAR filings.

What are XLO's key strengths?

Claude: Exceptional top-line growth of 589.9% YoY indicating strong market traction and product demand. Fortress balance sheet with $150.3M cash representing 92% of total assets and zero long-term debt, providing 6-7 years of runway at current burn rates.

What are the risks of investing in XLO?

Claude: Deeply unprofitable with operating margin of -111.6% and net margin of -75.3%, indicating business model not yet economically viable. Negative free cash flow of -$22.9M annually with ongoing cash burn despite revenue growth, raising concerns about path to profitability.

What is XLO's revenue and growth?

Xilio Therapeutics, Inc. reported revenue of $12.6M.

Does XLO pay dividends?

Xilio Therapeutics, Inc. does not currently pay dividends.

Where can I find XLO SEC filings?

Official SEC filings for Xilio Therapeutics, Inc. (CIK: 0001840233) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is XLO's EPS?

Xilio Therapeutics, Inc. has a diluted EPS of $-0.58.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is XLO a good stock to buy right now?

Based on our AI fundamental analysis in May 2026, Xilio Therapeutics, Inc. has a HOLD rating with 68% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is XLO stock overvalued or undervalued?

Valuation metrics for XLO: ROE of -13.1% (sector avg: 15%), net margin of -75.3% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy XLO stock in 2026?

Our dual AI analysis gives Xilio Therapeutics, Inc. a combined HOLD rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is XLO's free cash flow?

Xilio Therapeutics, Inc.'s operating cash flow is $-22.3M, with capital expenditures of $556.0K. FCF margin is -181.0%.

How does XLO compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -75.3% (avg: 12%), ROE -13.1% (avg: 15%), current ratio 3.59 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: May 16, 2026 | Data as of: 2026-03-31 | Powered by Claude AI