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Syndax Pharmaceuticals Inc (SNDX) Stock Fundamental Analysis & AI Rating 2026

SNDX Nasdaq Pharmaceutical Preparations DE CIK: 0001395937
Recently Updated • Analysis: Apr 16, 2026 • SEC Data: 2025-12-31
SELL
72% Conf
Pending
Analysis scheduled

📊 SNDX Key Takeaways

Revenue: $172.4M
Net Margin: -165.6%
Free Cash Flow: $-323.2M
Current Ratio: 4.40x
Debt/Equity: 0.31x
EPS: $-3.29
AI Rating: SELL with 72% confidence
Syndax Pharmaceuticals Inc (SNDX) receives a SELL rating with 72% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $172.4M, net profit margin of -165.6%, and return on equity (ROE) of -441.6%, Syndax Pharmaceuticals Inc demonstrates mixed fundamentals in the Healthcare sector. Below is our complete SNDX stock analysis for 2026.

Is Syndax Pharmaceuticals Inc (SNDX) a Good Investment?

Claude

Syndax exhibits exceptional 628% revenue growth indicating successful recent product commercialization, but faces catastrophic cash burn of $323M annually against only $134.9M in reserves, providing approximately 5 months of runway. Deep operating losses and negative margins across the board despite revenue growth signal either operational challenges or unsustainable cost structure, creating imminent refinancing risk.

Why Buy Syndax Pharmaceuticals Inc Stock? SNDX Key Strengths

Claude
  • + Exceptional revenue growth of 627.8% YoY suggesting successful drug commercialization
  • + Strong liquidity position with 4.4x current ratio and $134.9M cash reserves
  • + Conservative capital structure with 0.31x debt-to-equity ratio

SNDX Stock Risks: Syndax Pharmaceuticals Inc Investment Risks

Claude
  • ! Unsustainable cash burn of $323M annually with <5 months of cash runway remaining
  • ! Operating margin of -158.4% and net margin of -165.6% despite massive revenue growth
  • ! Negative operating cash flow of $323M indicates fundamental operational challenges beyond typical pharma R&D spending

Key Metrics to Watch

Claude
  • * Quarterly cash burn trend and months of cash runway
  • * Gross margin and operating expense leverage as commercialization scales
  • * Capital raise announcements or debt refinancing activities

Syndax Pharmaceuticals Inc (SNDX) Financial Metrics & Key Ratios

Revenue
$172.4M
Net Income
$-285.4M
EPS (Diluted)
$-3.29
Free Cash Flow
$-323.2M
Total Assets
$529.7M
Cash Position
$134.9M

💡 AI Analyst Insight

Strong liquidity with a 4.40x current ratio provides a solid financial cushion.

SNDX Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -158.4%
Net Margin -165.6%
ROE -441.6%
ROA -53.9%
FCF Margin -187.5%

SNDX vs Healthcare Sector: How Syndax Pharmaceuticals Inc Compares

How Syndax Pharmaceuticals Inc compares to Healthcare sector averages

Net Margin
SNDX -165.6%
vs
Sector Avg 12.0%
SNDX Sector
ROE
SNDX -441.6%
vs
Sector Avg 15.0%
SNDX Sector
Current Ratio
SNDX 4.4x
vs
Sector Avg 2.0x
SNDX Sector
Debt/Equity
SNDX 0.3x
vs
Sector Avg 0.6x
SNDX Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Syndax Pharmaceuticals Inc Stock Overvalued? SNDX Valuation Analysis 2026

Based on fundamental analysis, Syndax Pharmaceuticals Inc has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-441.6%
Sector avg: 15%
Net Profit Margin
-165.6%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.31x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Syndax Pharmaceuticals Inc Balance Sheet: SNDX Debt, Cash & Liquidity

Current Ratio
4.40x
Quick Ratio
4.12x
Debt/Equity
0.31x
Debt/Assets
87.8%
Interest Coverage
-2,730.84x
Long-term Debt
$20.0M

SNDX Revenue & Earnings Growth: 5-Year Financial Trend

SNDX 5-year financial data: Year 2021: Revenue $139.7M, Net Income -$56.0M, EPS $-1.84. Year 2022: Revenue $139.7M, Net Income -$73.2M, EPS $-1.87. Year 2023: Revenue $139.7M, Net Income $24.9M, EPS $0.46. Year 2024: Revenue $23.7M, Net Income -$149.3M, EPS $-2.46. Year 2025: Revenue $172.4M, Net Income -$209.4M, EPS $-2.98.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Syndax Pharmaceuticals Inc's revenue has grown significantly by 23% over the 5-year period, indicating strong business expansion. The most recent EPS of $-2.98 indicates the company is currently unprofitable.

SNDX Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-187.5%
Free cash flow / Revenue

SNDX Quarterly Earnings & Performance

Quarterly financial performance data for Syndax Pharmaceuticals Inc including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $12.5M -$60.7M $-0.70
Q2 2025 $3.5M -$68.1M $-0.80
Q1 2025 N/A -$72.4M $-0.85
Q3 2024 N/A -$41.1M $-0.73
Q2 2024 N/A -$41.1M $-0.64
Q3 2022 $12.4M -$20.6M $-0.40
Q2 2022 $379.0K -$22.9M $-0.44
Q1 2022 $379.0K -$27.7M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Syndax Pharmaceuticals Inc Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$323.0M
Cash generated from operations
Capital Expenditures
$187.0K
Investment in assets
Dividends
None
No dividend program

SNDX SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Syndax Pharmaceuticals Inc (CIK: 0001395937)

📋 Recent SEC Filings

Date Form Document Action
Feb 26, 2026 10-K sndx-20251231.htm View →
Feb 26, 2026 8-K sndx-20260226.htm View →
Feb 10, 2026 4 xslF345X05/ownership.xml View →
Feb 10, 2026 4 xslF345X05/ownership.xml View →
Feb 6, 2026 4 xslF345X05/ownership.xml View →

Frequently Asked Questions about SNDX

What is the AI rating for SNDX?

Syndax Pharmaceuticals Inc (SNDX) has an AI rating of SELL with 72% confidence, based on fundamental analysis of SEC EDGAR filings.

What are SNDX's key strengths?

Claude: Exceptional revenue growth of 627.8% YoY suggesting successful drug commercialization. Strong liquidity position with 4.4x current ratio and $134.9M cash reserves.

What are the risks of investing in SNDX?

Claude: Unsustainable cash burn of $323M annually with <5 months of cash runway remaining. Operating margin of -158.4% and net margin of -165.6% despite massive revenue growth.

What is SNDX's revenue and growth?

Syndax Pharmaceuticals Inc reported revenue of $172.4M.

Does SNDX pay dividends?

Syndax Pharmaceuticals Inc does not currently pay dividends.

Where can I find SNDX SEC filings?

Official SEC filings for Syndax Pharmaceuticals Inc (CIK: 0001395937) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is SNDX's EPS?

Syndax Pharmaceuticals Inc has a diluted EPS of $-3.29.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is SNDX a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Syndax Pharmaceuticals Inc has a SELL rating with 72% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is SNDX stock overvalued or undervalued?

Valuation metrics for SNDX: ROE of -441.6% (sector avg: 15%), net margin of -165.6% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy SNDX stock in 2026?

Our dual AI analysis gives Syndax Pharmaceuticals Inc a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is SNDX's free cash flow?

Syndax Pharmaceuticals Inc's operating cash flow is $-323.0M, with capital expenditures of $187.0K. FCF margin is -187.5%.

How does SNDX compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -165.6% (avg: 12%), ROE -441.6% (avg: 15%), current ratio 4.40 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 16, 2026 | Data as of: 2025-12-31 | Powered by Claude AI