← Back to All US Stocks

Nautilus Biotechnology, Inc. (NAUT) Stock Fundamental Analysis & AI Rating 2026

NAUT Nasdaq Laboratory Analytical Instruments CIK: 0001808805
Recently Updated • Analysis: Apr 13, 2026 • SEC Data: 2025-12-31
📅 Next earnings: Apr 28, 2026 (in 12 days) • Pre-market ET • All earnings →
Combined AI Rating
SELL
78% Confidence
AGREEMENT
STRONG SELL
88% Conf
SELL
68% Conf

📊 NAUT Key Takeaways

Revenue: N/A
Net Margin: N/A
Free Cash Flow: $-52.0M
Current Ratio: 13.33x
Debt/Equity: 0.00x
EPS: $-0.47
AI Rating: STRONG SELL with 88% confidence
Nautilus Biotechnology, Inc. (NAUT) receives a SELL rating with 78% confidence from our AI fundamental analysis based on SEC 10-K filings., and return on equity (ROE) of -37.6% Below is our complete NAUT stock analysis for 2026.

Is Nautilus Biotechnology, Inc. (NAUT) a Good Investment?

Claude

Nautilus Biotechnology is a pre-revenue stage biotech company burning through cash at $52M annually with only $12.4M in cash reserves (~3 months runway). Despite a strong balance sheet with $157M equity and minimal debt, the company faces critical near-term funding risk absent material revenue generation or capital raises. The unsustainable cash burn trajectory and absence of revenue visibility present severe fundamental challenges.

ChatGPT

Nautilus remains effectively pre-revenue with substantial net losses and deeply negative free cash flow, indicating unclear line-of-sight to self-sustaining operations. While the balance sheet shows high liquidity and no debt, cash burn is significant and raises financing risk absent near-term commercialization traction.

Why Buy Nautilus Biotechnology, Inc. Stock? NAUT Key Strengths

Claude
  • + Strong balance sheet with $157M stockholders' equity and zero long-term debt provides capital base for funding
  • + Excellent short-term liquidity with 13.33x current ratio demonstrates ability to meet near-term obligations
  • + Pre-revenue biotech model typical for laboratory instrumentation sector with potential long-term value creation if technology succeeds
ChatGPT
  • + Very strong liquidity (13.33x current ratio)
  • + Zero leverage (0.00x D/E) provides flexibility
  • + Low capex intensity supports capital-light model

NAUT Stock Risks: Nautilus Biotechnology, Inc. Investment Risks

Claude
  • ! Critical cash runway of approximately 3 months at current burn rate ($52M annual free cash flow burn vs $12.4M cash)
  • ! Zero revenue generation with no visible near-term commercialization pathway or revenue drivers
  • ! Annual net losses of $59M and operating losses of $1.8M indicate massive operating inefficiency and unproven business model
ChatGPT
  • ! Prolonged pre-revenue status and commercialization uncertainty
  • ! High cash burn and negative FCF heighten financing/dilution risk
  • ! Sustained negative ROE/ROA signal poor capital efficiency

Key Metrics to Watch

Claude
  • * Quarterly cash burn rate and total cash on hand (immediate existential metric)
  • * Revenue generation initiation and product commercialization milestones
  • * Secondary capital raises and equity offerings (necessary for survival at current burn rate)
ChatGPT
  • * Total cash and marketable securities
  • * Operating cash flow (quarterly burn)

Nautilus Biotechnology, Inc. (NAUT) Financial Metrics & Key Ratios

Revenue
N/A
Net Income
$-59.0M
EPS (Diluted)
$-0.47
Free Cash Flow
$-52.0M
Total Assets
$191.1M
Cash Position
$12.4M

💡 AI Analyst Insight

Strong liquidity with a 13.33x current ratio provides a solid financial cushion.

NAUT Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -37.6%
ROA -30.9%
FCF Margin N/A

NAUT vs Industrial Sector: How Nautilus Biotechnology, Inc. Compares

How Nautilus Biotechnology, Inc. compares to Industrial sector averages

Net Margin
NAUT 0.0%
vs
Sector Avg 10.0%
NAUT Sector
ROE
NAUT -37.6%
vs
Sector Avg 15.0%
NAUT Sector
Current Ratio
NAUT 13.3x
vs
Sector Avg 1.8x
NAUT Sector
Debt/Equity
NAUT 0.0x
vs
Sector Avg 0.7x
NAUT Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Nautilus Biotechnology, Inc. Stock Overvalued? NAUT Valuation Analysis 2026

Based on fundamental analysis, Nautilus Biotechnology, Inc. has mixed fundamental signals relative to the Industrial sector in 2026.

Return on Equity
-37.6%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 10%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.7x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Nautilus Biotechnology, Inc. Balance Sheet: NAUT Debt, Cash & Liquidity

Current Ratio
13.33x
Quick Ratio
13.33x
Debt/Equity
0.00x
Debt/Assets
17.9%
Interest Coverage
N/A
Long-term Debt
N/A

NAUT Revenue & Earnings Growth: 5-Year Financial Trend

NAUT 5-year financial data:
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Nautilus Biotechnology, Inc.'s revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-0.56 indicates the company is currently unprofitable.

NAUT Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

Nautilus Biotechnology, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$50.7M
Cash generated from operations
Capital Expenditures
$1.3M
Investment in assets
Dividends
None
No dividend program

NAUT SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Nautilus Biotechnology, Inc. (CIK: 0001808805)

📋 Recent SEC Filings

Date Form Document Action
Mar 4, 2026 4 xslF345X05/wk-form4_1772667437.xml View →
Mar 4, 2026 4 xslF345X05/wk-form4_1772663494.xml View →
Mar 4, 2026 4 xslF345X05/wk-form4_1772663489.xml View →
Mar 4, 2026 4 xslF345X05/wk-form4_1772663485.xml View →
Mar 4, 2026 4 xslF345X05/wk-form4_1772663480.xml View →

Frequently Asked Questions about NAUT

What is the AI rating for NAUT?

Nautilus Biotechnology, Inc. (NAUT) has a Combined AI Rating of SELL from Claude (STRONG SELL) and ChatGPT (SELL) with 78% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are NAUT's key strengths?

Claude: Strong balance sheet with $157M stockholders' equity and zero long-term debt provides capital base for funding. Excellent short-term liquidity with 13.33x current ratio demonstrates ability to meet near-term obligations. ChatGPT: Very strong liquidity (13.33x current ratio). Zero leverage (0.00x D/E) provides flexibility.

What are the risks of investing in NAUT?

Claude: Critical cash runway of approximately 3 months at current burn rate ($52M annual free cash flow burn vs $12.4M cash). Zero revenue generation with no visible near-term commercialization pathway or revenue drivers. ChatGPT: Prolonged pre-revenue status and commercialization uncertainty. High cash burn and negative FCF heighten financing/dilution risk.

What is NAUT's revenue and growth?

Nautilus Biotechnology, Inc. reported revenue of N/A.

Does NAUT pay dividends?

Nautilus Biotechnology, Inc. does not currently pay dividends.

Where can I find NAUT SEC filings?

Official SEC filings for Nautilus Biotechnology, Inc. (CIK: 0001808805) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is NAUT's EPS?

Nautilus Biotechnology, Inc. has a diluted EPS of $-0.47.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is NAUT a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Nautilus Biotechnology, Inc. has a SELL rating with 78% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is NAUT stock overvalued or undervalued?

Valuation metrics for NAUT: ROE of -37.6% (sector avg: 15%), net margin of N/A (sector avg: 10%). Compare these metrics with sector averages to assess valuation.

Should I buy NAUT stock in 2026?

Our dual AI analysis gives Nautilus Biotechnology, Inc. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is NAUT's free cash flow?

Nautilus Biotechnology, Inc.'s operating cash flow is $-50.7M, with capital expenditures of $1.3M.

How does NAUT compare to other Industrial stocks?

Vs Industrial sector averages: Net margin N/A (avg: 10%), ROE -37.6% (avg: 15%), current ratio 13.33 (avg: 1.8).

Top Rated Stocks
NSSC 92% MLI 92% MELI 92% MDXG 92% MANH 92% INVA 92% GGG 92% GCT 92% FTNT 92% FSLR 92%
Sector: All Industrial Stocks →
Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 13, 2026 | Data as of: 2025-12-31 | Powered by Claude AI