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International Stem Cell CORP (ISCO) Stock Fundamental Analysis & AI Rating 2026

ISCO OTC Pharmaceutical Preparations DE CIK: 0001355790
Updated This Month • Analysis: Mar 29, 2026 • SEC Data: 2025-09-30
Combined AI Rating
SELL
87% Confidence
AGREEMENT
STRONG SELL
92% Conf
SELL
82% Conf

📊 ISCO Key Takeaways

Revenue: $6.9M
Net Margin: -1.0%
Free Cash Flow: $-64.0K
Current Ratio: 0.80x
Debt/Equity: N/A
EPS: $-0.01
AI Rating: STRONG SELL with 92% confidence
International Stem Cell CORP (ISCO) receives a SELL rating with 87% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $6.9M, net profit margin of -1.0%, International Stem Cell CORP demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ISCO stock analysis for 2026.

Is International Stem Cell CORP (ISCO) a Good Investment?

Claude

International Stem Cell Corporation exhibits severe financial distress with negative stockholders' equity of -$3.8M, indicating the company is technically insolvent. Despite modest revenue growth of 16.6% YoY to $6.9M, the company burns cash operationally (-$24K OCF) and has negative free cash flow of -$64K, with dangerously low liquidity ratios that threaten near-term viability.

ChatGPT

International Stem Cell shows some top-line momentum, with revenue up 16.6% year over year and operations roughly near break-even. However, the quality of that improvement is weak because margins remain minimal, free cash flow is negative, liquidity is strained, and the balance sheet is severely impaired by negative equity. Fundamentally, this looks like a fragile business with limited financial flexibility despite modest revenue growth.

Why Buy International Stem Cell CORP Stock? ISCO Key Strengths

Claude
  • + Revenue growth of 16.6% YoY demonstrates demand for core products/services
  • + Positive operating income of $46K shows some operational profitability before capital structure effects
  • + Cash position of $966K provides minimal runway for operations
ChatGPT
  • + Revenue grew 16.6% year over year, indicating continued demand or commercial progress
  • + Operating income turned slightly positive, showing the business is close to breakeven at the operating level
  • + Cash burn is relatively modest in the latest period compared with revenue size

ISCO Stock Risks: International Stem Cell CORP Investment Risks

Claude
  • ! Negative stockholders' equity of -$3.8M indicates technical insolvency and existential solvency risk
  • ! Current ratio of 0.80x and quick ratio of 0.46x show severe liquidity crisis with current liabilities exceeding current assets
  • ! Negative free cash flow of -$64K combined with operating cash burn suggests inability to fund operations or growth without capital injection
  • ! Interest coverage ratio of 0.4x indicates inability to service debt obligations from operating earnings
  • ! No insider buying activity in last 90 days suggests lack of confidence from management
ChatGPT
  • ! Negative stockholders equity signals a highly stressed balance sheet and limits financial resilience
  • ! Current ratio of 0.80x and quick ratio of 0.46x indicate weak short-term liquidity
  • ! Net income and free cash flow remain negative, so profitability improvement is not yet durable

Key Metrics to Watch

Claude
  • * Operating cash flow trend and path to cash flow positivity
  • * Stockholders' equity recovery and balance sheet restructuring
  • * Revenue sustainability and gross margin realization if disclosed
  • * Cash runway duration given current burn rate
  • * Debt restructuring or equity infusion announcements
ChatGPT
  • * Sustained positive operating cash flow and free cash flow
  • * Improvement in current ratio and reduction of balance sheet deficit

International Stem Cell CORP (ISCO) Financial Metrics & Key Ratios

Revenue
$6.9M
Net Income
$-70.0K
EPS (Diluted)
$-0.01
Free Cash Flow
$-64.0K
Total Assets
$5.3M
Cash Position
$966.0K

💡 AI Analyst Insight

The current ratio below 1.0x warrants monitoring of short-term liquidity.

ISCO Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin 0.7%
Net Margin -1.0%
ROE N/A
ROA -1.3%
FCF Margin -0.9%

ISCO vs Healthcare Sector: How International Stem Cell CORP Compares

How International Stem Cell CORP compares to Healthcare sector averages

Net Margin
ISCO -1.0%
vs
Sector Avg 12.0%
ISCO Sector
ROE
ISCO 0.0%
vs
Sector Avg 15.0%
ISCO Sector
Current Ratio
ISCO 0.8x
vs
Sector Avg 2.0x
ISCO Sector
Debt/Equity
ISCO 0.0x
vs
Sector Avg 0.6x
ISCO Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is International Stem Cell CORP Stock Overvalued? ISCO Valuation Analysis 2026

Based on fundamental analysis, International Stem Cell CORP has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
N/A
Sector avg: 15%
Net Profit Margin
-1.0%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
N/A
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

International Stem Cell CORP Balance Sheet: ISCO Debt, Cash & Liquidity

Current Ratio
0.80x
Quick Ratio
0.46x
Debt/Equity
N/A
Debt/Assets
90.1%
Interest Coverage
0.40x
Long-term Debt
N/A

ISCO Revenue & Earnings Growth: 5-Year Financial Trend

ISCO 5-year financial data: Year 2021: Revenue $7.2M, Net Income -$2.7M, EPS N/A. Year 2022: Revenue $8.2M, Net Income -$899.0K, EPS $-0.11. Year 2023: Revenue $8.2M, Net Income -$331.0K, EPS $-0.04. Year 2024: Revenue $9.1M, Net Income -$131.0K, EPS $-0.02. Year 2025: Revenue $9.1M, Net Income -$209.0K, EPS $-0.03.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: International Stem Cell CORP's revenue has grown significantly by 27% over the 5-year period, indicating strong business expansion. The most recent EPS of $-0.03 indicates the company is currently unprofitable.

ISCO Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-0.9%
Free cash flow / Revenue

ISCO Quarterly Earnings & Performance

Quarterly financial performance data for International Stem Cell CORP including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $2.2M $57.0K $0.00
Q2 2025 $2.3M -$95.0K $-0.01
Q1 2025 $2.1M -$214.0K $-0.03
Q3 2024 $2.0M -$34.0K $0.02
Q2 2024 $1.8M -$34.0K $-0.01
Q1 2024 $2.1M -$34.0K $-0.03
Q3 2023 $1.7M -$2.0K $0.02
Q2 2023 $1.8M -$2.0K $0.03

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

International Stem Cell CORP Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$24.0K
Cash generated from operations
Capital Expenditures
$40.0K
Investment in assets
Dividends
None
No dividend program

ISCO SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for International Stem Cell CORP (CIK: 0001355790)

📋 Recent SEC Filings

Date Form Document Action
Mar 30, 2026 10-K isco-20251231.htm View →
Nov 18, 2025 8-K intlstemcell_8k.htm View →
Nov 13, 2025 10-Q isco-20250930.htm View →
Sep 16, 2025 8-K intlstemcell_8k.htm View →
Aug 14, 2025 10-Q isco-20250630.htm View →

Frequently Asked Questions about ISCO

What is the AI rating for ISCO?

International Stem Cell CORP (ISCO) has a Combined AI Rating of SELL from Claude (STRONG SELL) and ChatGPT (SELL) with 87% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are ISCO's key strengths?

Claude: Revenue growth of 16.6% YoY demonstrates demand for core products/services. Positive operating income of $46K shows some operational profitability before capital structure effects. ChatGPT: Revenue grew 16.6% year over year, indicating continued demand or commercial progress. Operating income turned slightly positive, showing the business is close to breakeven at the operating level.

What are the risks of investing in ISCO?

Claude: Negative stockholders' equity of -$3.8M indicates technical insolvency and existential solvency risk. Current ratio of 0.80x and quick ratio of 0.46x show severe liquidity crisis with current liabilities exceeding current assets. ChatGPT: Negative stockholders equity signals a highly stressed balance sheet and limits financial resilience. Current ratio of 0.80x and quick ratio of 0.46x indicate weak short-term liquidity.

What is ISCO's revenue and growth?

International Stem Cell CORP reported revenue of $6.9M.

Does ISCO pay dividends?

International Stem Cell CORP does not currently pay dividends.

Where can I find ISCO SEC filings?

Official SEC filings for International Stem Cell CORP (CIK: 0001355790) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ISCO's EPS?

International Stem Cell CORP has a diluted EPS of $-0.01.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is ISCO a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, International Stem Cell CORP has a SELL rating with 87% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is ISCO stock overvalued or undervalued?

Valuation metrics for ISCO: ROE of N/A (sector avg: 15%), net margin of -1.0% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy ISCO stock in 2026?

Our dual AI analysis gives International Stem Cell CORP a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ISCO's free cash flow?

International Stem Cell CORP's operating cash flow is $-24.0K, with capital expenditures of $40.0K. FCF margin is -0.9%.

How does ISCO compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -1.0% (avg: 12%), ROE N/A (avg: 15%), current ratio 0.80 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 29, 2026 | Data as of: 2025-09-30 | Powered by Claude AI