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IO Biotech, Inc. (IOBT) Stock Fundamental Analysis & AI Rating 2026

IOBT Nasdaq Pharmaceutical Preparations DE CIK: 0001865494
Updated This Month • Analysis: Mar 29, 2026 • SEC Data: 2025-09-30
Combined AI Rating
STRONG SELL
93% Confidence
STRONG AGREEMENT
STRONG SELL
95% Conf
STRONG SELL
91% Conf

📊 IOBT Key Takeaways

Revenue: N/A
Net Margin: N/A
Free Cash Flow: $-61.4M
Current Ratio: 2.01x
Debt/Equity: 18.29x
EPS: $-0.86
AI Rating: STRONG SELL with 95% confidence
IO Biotech, Inc. (IOBT) receives a STRONG SELL rating with 93% confidence from our AI fundamental analysis based on SEC 10-K filings., and return on equity (ROE) of -6,258.6% Below is our complete IOBT stock analysis for 2026.

Is IO Biotech, Inc. (IOBT) a Good Investment?

Claude

IO Biotech is a pre-revenue pharmaceutical company with severe financial distress, burning $61.4M in operating cash flow with only $30.7M in cash reserves, indicating a runway of approximately 6 months. The company's negative net income of -$57.0M, combined with a debt-to-equity ratio of 18.29x and stockholders' equity of only $911K, suggests imminent solvency concerns and substantial dilution risk for existing shareholders.

ChatGPT

IO Biotech’s fundamentals are very weak: the company has no reported revenue, continues to post large operating and net losses, and is consuming cash at a rate that appears unsustainable relative to its cash balance. While liquidity ratios look acceptable on the surface, equity is nearly exhausted and leverage is extremely high, making the business heavily dependent on external funding rather than internally generated financial strength.

Why Buy IO Biotech, Inc. Stock? IOBT Key Strengths

Claude
  • + Adequate short-term liquidity with current ratio of 2.01x providing temporary operational flexibility
  • + Substantial cash position of $30.7M relative to total assets, though insufficient relative to burn rate
  • + No insider selling activity in last 90 days suggests management confidence, though absence of insider buying is notable
ChatGPT
  • + Cash and equivalents of $30.66M provide some near-term operating flexibility
  • + Current and quick ratios of 2.01x indicate near-term liabilities are currently covered by liquid assets
  • + Diluted EPS improved year over year, suggesting some loss-per-share moderation

IOBT Stock Risks: IO Biotech, Inc. Investment Risks

Claude
  • ! Severe cash burn of $61.4M annually with only 6 months of runway at current rate, creating critical funding risk
  • ! Pre-revenue status with no commercial product monetization despite operating as a pharmaceutical company
  • ! Extremely high leverage with debt-to-equity of 18.29x and minimal equity cushion of $911K, indicating bankruptcy risk if cash depletes
  • ! Negative interest coverage of -215.6x shows inability to service debt from operations
  • ! Operating losses of -$65.1M demonstrate fundamental business model failure without path to profitability
ChatGPT
  • ! No revenue base means the business is not yet demonstrating commercial traction or self-funding capacity
  • ! Operating cash outflow of $61.37M and free cash flow of -$61.43M imply severe cash burn relative to available cash
  • ! Stockholders’ equity of just $0.91M and debt/equity of 18.29x indicate a highly fragile balance sheet

Key Metrics to Watch

Claude
  • * Monthly cash burn rate and remaining runway to assess immediate solvency timeline
  • * Clinical trial progress and regulatory milestones that could support future revenue potential
  • * Additional financing activities and dilution impact on existing shareholders
  • * Operating cash flow trajectory and quarterly burn rate changes
ChatGPT
  • * Quarterly cash burn versus cash balance/runway
  • * Progress toward revenue generation and reduction in operating losses

IO Biotech, Inc. (IOBT) Financial Metrics & Key Ratios

Revenue
N/A
Net Income
$-57.0M
EPS (Diluted)
$-0.86
Free Cash Flow
$-61.4M
Total Assets
$40.0M
Cash Position
$30.7M

💡 AI Analyst Insight

Strong liquidity with a 2.01x current ratio provides a solid financial cushion.

IOBT Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -6,258.6%
ROA -142.7%
FCF Margin N/A

IOBT vs Healthcare Sector: How IO Biotech, Inc. Compares

How IO Biotech, Inc. compares to Healthcare sector averages

Net Margin
IOBT 0.0%
vs
Sector Avg 12.0%
IOBT Sector
ROE
IOBT -6,258.6%
vs
Sector Avg 15.0%
IOBT Sector
Current Ratio
IOBT 2.0x
vs
Sector Avg 2.0x
IOBT Sector
Debt/Equity
IOBT 18.3x
vs
Sector Avg 0.6x
IOBT Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is IO Biotech, Inc. Stock Overvalued? IOBT Valuation Analysis 2026

Based on fundamental analysis, IO Biotech, Inc. shows some fundamental concerns relative to the Healthcare sector in 2026.

Return on Equity
-6,258.6%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
18.29x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

IO Biotech, Inc. Balance Sheet: IOBT Debt, Cash & Liquidity

Current Ratio
2.01x
Quick Ratio
2.01x
Debt/Equity
18.29x
Debt/Assets
97.7%
Interest Coverage
-215.59x
Long-term Debt
$16.7M

IOBT Revenue & Earnings Growth: 5-Year Financial Trend

IOBT 5-year financial data:
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: IO Biotech, Inc.'s revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-1.98 indicates the company is currently unprofitable.

IOBT Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

IO Biotech, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$61.4M
Cash generated from operations
Capital Expenditures
$58.0K
Investment in assets
Dividends
None
No dividend program

IOBT SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for IO Biotech, Inc. (CIK: 0001865494)

📋 Recent SEC Filings

Date Form Document Action
Mar 31, 2026 8-K d87973d8k.htm View →
Feb 13, 2026 8-K d113832d8k.htm View →
Jan 30, 2026 8-K d13704d8k.htm View →
Jan 21, 2026 8-K d26457d8k.htm View →
Dec 19, 2025 8-K d71494d8k.htm View →

Frequently Asked Questions about IOBT

What is the AI rating for IOBT?

IO Biotech, Inc. (IOBT) has a Combined AI Rating of STRONG SELL from Claude (STRONG SELL) and ChatGPT (STRONG SELL) with 93% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are IOBT's key strengths?

Claude: Adequate short-term liquidity with current ratio of 2.01x providing temporary operational flexibility. Substantial cash position of $30.7M relative to total assets, though insufficient relative to burn rate. ChatGPT: Cash and equivalents of $30.66M provide some near-term operating flexibility. Current and quick ratios of 2.01x indicate near-term liabilities are currently covered by liquid assets.

What are the risks of investing in IOBT?

Claude: Severe cash burn of $61.4M annually with only 6 months of runway at current rate, creating critical funding risk. Pre-revenue status with no commercial product monetization despite operating as a pharmaceutical company. ChatGPT: No revenue base means the business is not yet demonstrating commercial traction or self-funding capacity. Operating cash outflow of $61.37M and free cash flow of -$61.43M imply severe cash burn relative to available cash.

What is IOBT's revenue and growth?

IO Biotech, Inc. reported revenue of N/A.

Does IOBT pay dividends?

IO Biotech, Inc. does not currently pay dividends.

Where can I find IOBT SEC filings?

Official SEC filings for IO Biotech, Inc. (CIK: 0001865494) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is IOBT's EPS?

IO Biotech, Inc. has a diluted EPS of $-0.86.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is IOBT a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, IO Biotech, Inc. has a STRONG SELL rating with 93% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is IOBT stock overvalued or undervalued?

Valuation metrics for IOBT: ROE of -6,258.6% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy IOBT stock in 2026?

Our dual AI analysis gives IO Biotech, Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is IOBT's free cash flow?

IO Biotech, Inc.'s operating cash flow is $-61.4M, with capital expenditures of $58.0K.

How does IOBT compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -6,258.6% (avg: 15%), current ratio 2.01 (avg: 2).

Is IO Biotech, Inc. carrying too much debt?

IOBT has a debt-to-equity ratio of 18.29x, which is above the Healthcare sector average of 0.6x. However, the current ratio of 2.01 suggests adequate short-term liquidity.

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 29, 2026 | Data as of: 2025-09-30 | Powered by Claude AI