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INSMED Inc (INSM) Stock Fundamental Analysis & AI Rating 2026

INSM Nasdaq Pharmaceutical Preparations VA CIK: 0001104506
Updated This Month • Analysis: Mar 29, 2026 • SEC Data: 2025-12-31
Combined AI Rating
SELL
88% Confidence
STRONG AGREEMENT
SELL
92% Conf
SELL
85% Conf

📊 INSM Key Takeaways

Revenue: $606.4M
Net Margin: -210.5%
Free Cash Flow: $-967.6M
Current Ratio: 3.83x
Debt/Equity: 0.74x
EPS: $-6.42
AI Rating: SELL with 92% confidence
INSMED Inc (INSM) receives a SELL rating with 88% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $606.4M, net profit margin of -210.5%, and return on equity (ROE) of -172.8%, INSMED Inc demonstrates mixed fundamentals in the Healthcare sector. Below is our complete INSM stock analysis for 2026.

Is INSMED Inc (INSM) a Good Investment?

Claude

Insmed exhibits severe operational losses despite strong revenue growth of 66.7% YoY, indicating the company is burning significant cash to drive sales. With negative free cash flow of -$967.6M and an operating cash burn rate of -$935M, the company's financial runway is limited, creating substantial existential risk even with $510.4M in cash reserves.

ChatGPT

Insmed is delivering strong top-line growth, with revenue up 66.7% year over year, but that growth is currently low quality because it is accompanied by deeply negative operating and free cash flow margins. The balance sheet and liquidity position provide some runway, yet the scale of losses, weak gross margin, and negative interest coverage indicate the business remains heavily dependent on continued external funding or major operating improvement.

Why Buy INSMED Inc Stock? INSM Key Strengths

Claude
  • + Strong revenue growth of 66.7% YoY demonstrates significant commercial traction and market demand
  • + Healthy liquidity position with current ratio of 3.83x and $510.4M in cash providing near-term operational buffer
  • + Moderate leverage with debt-to-equity ratio of 0.74x indicates manageable debt burden relative to equity base
ChatGPT
  • + Revenue growth is very strong at 66.7% year over year
  • + Liquidity is solid with a 3.83x current ratio and $510.44M in cash
  • + Debt/equity of 0.74x is manageable relative to many development-stage biotech peers

INSM Stock Risks: INSMED Inc Investment Risks

Claude
  • ! Severe profitability crisis with -210.5% net margin and -205.6% operating margin indicating unsustainable unit economics
  • ! Catastrophic cash burn of -$967.6M in free cash flow annually will exhaust $510.4M cash reserves within 6 months at current burn rate
  • ! Negative interest coverage of -14.9x shows company cannot service debt from operations, forcing reliance on capital markets or asset liquidation
  • ! Operating losses of -$1.2B on revenue of only $606.4M indicate fundamental business model challenges, not temporary startup losses
ChatGPT
  • ! Operating margin of -205.6% shows the core business is far from self-sustaining
  • ! Free cash flow of -$967.58M and operating cash flow of -$935.01M imply heavy cash burn
  • ! Gross margin of 15.5% is weak for a pharmaceutical company and limits operating leverage

Key Metrics to Watch

Claude
  • * Quarterly operating cash flow trend and projected cash runway duration
  • * Gross margin expansion pathway as product mix matures and manufacturing scales
  • * Path to operating profitability with timeline and key milestones
ChatGPT
  • * Operating cash burn and free cash flow trend
  • * Gross margin and operating margin improvement

INSMED Inc (INSM) Financial Metrics & Key Ratios

Revenue
$606.4M
Net Income
$-1.3B
EPS (Diluted)
$-6.42
Free Cash Flow
$-967.6M
Total Assets
$2.3B
Cash Position
$510.4M

💡 AI Analyst Insight

Strong liquidity with a 3.83x current ratio provides a solid financial cushion.

INSM Profit Margin, ROE & Profitability Analysis

Gross Margin 15.5%
Operating Margin -205.6%
Net Margin -210.5%
ROE -172.8%
ROA -56.4%
FCF Margin -159.6%

INSM vs Healthcare Sector: How INSMED Inc Compares

How INSMED Inc compares to Healthcare sector averages

Net Margin
INSM -210.5%
vs
Sector Avg 12.0%
INSM Sector
ROE
INSM -172.8%
vs
Sector Avg 15.0%
INSM Sector
Current Ratio
INSM 3.8x
vs
Sector Avg 2.0x
INSM Sector
Debt/Equity
INSM 0.7x
vs
Sector Avg 0.6x
INSM Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is INSMED Inc Stock Overvalued? INSM Valuation Analysis 2026

Based on fundamental analysis, INSMED Inc shows some fundamental concerns relative to the Healthcare sector in 2026.

Return on Equity
-172.8%
Sector avg: 15%
Net Profit Margin
-210.5%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.74x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

INSMED Inc Balance Sheet: INSM Debt, Cash & Liquidity

Current Ratio
3.83x
Quick Ratio
3.54x
Debt/Equity
0.74x
Debt/Assets
67.4%
Interest Coverage
-14.88x
Long-term Debt
$546.8M

INSM Revenue & Earnings Growth: 5-Year Financial Trend

INSM 5-year financial data: Year 2021: Revenue $188.5M, Net Income -$254.3M, EPS $-3.01. Year 2022: Revenue $245.4M, Net Income -$294.1M, EPS $-3.01. Year 2023: Revenue $305.2M, Net Income -$434.7M, EPS $-3.88. Year 2024: Revenue $363.7M, Net Income -$481.5M, EPS $-3.91. Year 2025: Revenue $606.4M, Net Income -$749.6M, EPS $-5.34.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: INSMED Inc's revenue has grown significantly by 222% over the 5-year period, indicating strong business expansion. The most recent EPS of $-5.34 indicates the company is currently unprofitable.

INSM Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-159.6%
Free cash flow / Revenue

INSM Quarterly Earnings & Performance

Quarterly financial performance data for INSMED Inc including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $93.4M -$220.5M $-1.27
Q2 2025 $90.3M -$300.6M $-1.70
Q1 2025 $75.5M -$157.1M $-1.06
Q3 2024 $79.1M -$158.9M $-1.11
Q2 2024 $77.2M -$244.8M $-1.78
Q1 2024 $65.2M -$157.1M $-1.06
Q3 2023 $67.7M -$131.1M $-1.09
Q2 2023 $65.2M -$95.6M $-0.80

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

INSMED Inc Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$935.0M
Cash generated from operations
Capital Expenditures
$32.6M
Investment in assets
Dividends
None
No dividend program

INSM SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for INSMED Inc (CIK: 0001104506)

📋 Recent SEC Filings

Date Form Document Action
Apr 8, 2026 4 xslF345X06/wk-form4_1775680879.xml View →
Apr 7, 2026 8-K ef20070042_8k.htm View →
Apr 3, 2026 4 xslF345X06/wk-form4_1775246852.xml View →
Apr 1, 2026 DEF 14A insm-20260401.htm View →
Mar 31, 2026 4 xslF345X06/wk-form4_1774988003.xml View →

Frequently Asked Questions about INSM

What is the AI rating for INSM?

INSMED Inc (INSM) has a Combined AI Rating of SELL from Claude (SELL) and ChatGPT (SELL) with 88% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are INSM's key strengths?

Claude: Strong revenue growth of 66.7% YoY demonstrates significant commercial traction and market demand. Healthy liquidity position with current ratio of 3.83x and $510.4M in cash providing near-term operational buffer. ChatGPT: Revenue growth is very strong at 66.7% year over year. Liquidity is solid with a 3.83x current ratio and $510.44M in cash.

What are the risks of investing in INSM?

Claude: Severe profitability crisis with -210.5% net margin and -205.6% operating margin indicating unsustainable unit economics. Catastrophic cash burn of -$967.6M in free cash flow annually will exhaust $510.4M cash reserves within 6 months at current burn rate. ChatGPT: Operating margin of -205.6% shows the core business is far from self-sustaining. Free cash flow of -$967.58M and operating cash flow of -$935.01M imply heavy cash burn.

What is INSM's revenue and growth?

INSMED Inc reported revenue of $606.4M.

Does INSM pay dividends?

INSMED Inc does not currently pay dividends.

Where can I find INSM SEC filings?

Official SEC filings for INSMED Inc (CIK: 0001104506) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is INSM's EPS?

INSMED Inc has a diluted EPS of $-6.42.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is INSM a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, INSMED Inc has a SELL rating with 88% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is INSM stock overvalued or undervalued?

Valuation metrics for INSM: ROE of -172.8% (sector avg: 15%), net margin of -210.5% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy INSM stock in 2026?

Our dual AI analysis gives INSMED Inc a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is INSM's free cash flow?

INSMED Inc's operating cash flow is $-935.0M, with capital expenditures of $32.6M. FCF margin is -159.6%.

How does INSM compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -210.5% (avg: 12%), ROE -172.8% (avg: 15%), current ratio 3.83 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 29, 2026 | Data as of: 2025-12-31 | Powered by Claude AI