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Cue Biopharma, Inc. (CUE) Stock Fundamental Analysis & AI Rating 2026

CUE Nasdaq Pharmaceutical Preparations DE CIK: 0001645460
Updated This Month • Analysis: Mar 23, 2026 • SEC Data: 2025-12-31
Combined AI Rating
SELL
84% Confidence
STRONG AGREEMENT
SELL
85% Conf
SELL
84% Conf

📊 CUE Key Takeaways

Revenue: $27.5M
Net Margin: -96.9%
Free Cash Flow: $-21.9M
Current Ratio: 2.74x
Debt/Equity: 0.00x
EPS: $-0.28
AI Rating: SELL with 85% confidence
Cue Biopharma, Inc. (CUE) receives a SELL rating with 84% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $27.5M, net profit margin of -96.9%, and return on equity (ROE) of -100.6%, Cue Biopharma, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete CUE stock analysis for 2026.

Is Cue Biopharma, Inc. (CUE) a Good Investment?

Claude

Cue Biopharma exhibits severe financial distress with massive operating losses (-96.7% margin) despite 7,793% revenue growth, indicating unsustainable burn rate and pre-commercial stage losses. The company is burning cash at an alarming rate (-$21.7M operating cash flow on $27.5M revenue) and will exhaust its $27.1M cash reserve within 14 months at current burn, leaving minimal runway for clinical development.

ChatGPT

Cue Biopharma shows a sharp revenue increase, but profitability quality remains weak because operating and net margins are still deeply negative and free cash flow remains materially negative. The balance sheet is relatively clean with no long-term debt and solid near-term liquidity, but continued cash burn and negative returns on assets and equity suggest the business model is not yet financially self-sustaining.

Why Buy Cue Biopharma, Inc. Stock? CUE Key Strengths

Claude
  • + Strong liquidity position with $27.1M cash and 2.74x current ratio providing near-term operational flexibility
  • + Dramatic 7,793% revenue growth suggests early commercialization or partnerships beginning to generate income
  • + Zero long-term debt reduces financial leverage risk and future solvency concerns
ChatGPT
  • + Strong liquidity with $27.14M in cash and a 2.74x current ratio
  • + No long-term debt, which reduces balance-sheet risk
  • + Revenue growth was exceptionally strong year over year, indicating potential partnership or milestone-driven inflows

CUE Stock Risks: Cue Biopharma, Inc. Investment Risks

Claude
  • ! Severe cash burn of -$21.9M free cash flow with only 14 months of runway at current burn rate before insolvency
  • ! Operating margin of -96.7% and net margin of -96.9% indicate fundamental unprofitability and no path to profitability visible
  • ! Negative ROE (-100.6%) and ROA (-63.0%) demonstrate value destruction and inefficient capital deployment
  • ! Operating cash outflows of -$21.7M on $27.5M revenue indicates business model not yet sustainable
ChatGPT
  • ! Operating and net margins remain near -97%, showing severe unprofitability
  • ! Free cash flow of -$21.86M indicates continued heavy cash burn
  • ! Revenue growth quality may be weak or non-recurring if driven by milestone or collaboration payments rather than durable commercialization

Key Metrics to Watch

Claude
  • * Monthly cash burn rate and cash runway remaining
  • * Path to operating profitability and timeline to breakeven
  • * Revenue growth sustainability and gross margin realization
ChatGPT
  • * Quarterly operating cash burn relative to cash balance
  • * Sustainability and composition of revenue growth versus recurring operating losses

Cue Biopharma, Inc. (CUE) Financial Metrics & Key Ratios

Revenue
$27.5M
Net Income
$-26.6M
EPS (Diluted)
$-0.28
Free Cash Flow
$-21.9M
Total Assets
$42.2M
Cash Position
$27.1M

💡 AI Analyst Insight

Strong liquidity with a 2.74x current ratio provides a solid financial cushion.

CUE Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -96.7%
Net Margin -96.9%
ROE -100.6%
ROA -63.0%
FCF Margin -79.6%

CUE vs Healthcare Sector: How Cue Biopharma, Inc. Compares

How Cue Biopharma, Inc. compares to Healthcare sector averages

Net Margin
CUE -96.9%
vs
Sector Avg 12.0%
CUE Sector
ROE
CUE -100.6%
vs
Sector Avg 15.0%
CUE Sector
Current Ratio
CUE 2.7x
vs
Sector Avg 2.0x
CUE Sector
Debt/Equity
CUE 0.0x
vs
Sector Avg 0.6x
CUE Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Cue Biopharma, Inc. Stock Overvalued? CUE Valuation Analysis 2026

Based on fundamental analysis, Cue Biopharma, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-100.6%
Sector avg: 15%
Net Profit Margin
-96.9%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Cue Biopharma, Inc. Balance Sheet: CUE Debt, Cash & Liquidity

Current Ratio
2.74x
Quick Ratio
2.74x
Debt/Equity
0.00x
Debt/Assets
37.4%
Interest Coverage
-265.52x
Long-term Debt
$0.0

CUE Revenue & Earnings Growth: 5-Year Financial Trend

CUE 5-year financial data: Year 2021: Revenue $14.9M, Net Income -$44.8M, EPS N/A. Year 2022: Revenue $14.9M, Net Income -$44.2M, EPS $-1.41. Year 2023: Revenue $5.5M, Net Income -$53.0M, EPS $-1.49. Year 2024: Revenue $9.3M, Net Income -$50.7M, EPS $-1.11. Year 2025: Revenue $27.5M, Net Income -$40.7M, EPS $-0.72.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Cue Biopharma, Inc.'s revenue has grown significantly by 84% over the 5-year period, indicating strong business expansion. The most recent EPS of $-0.72 indicates the company is currently unprofitable.

CUE Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-79.6%
Free cash flow / Revenue

CUE Quarterly Earnings & Performance

Quarterly financial performance data for Cue Biopharma, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $2.1M -$7.4M $-0.07
Q2 2025 $2.7M -$8.5M $-0.09
Q1 2025 $421.0K -$12.3M $-0.17
Q3 2024 $2.1M -$8.7M $-0.17
Q2 2024 $1.4M -$10.2M $-0.20
Q1 2024 $187.0K -$12.3M $-0.25
Q3 2023 $68.0K -$11.0M $-0.24
Q2 2023 $26.0K -$13.2M $-0.29

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Cue Biopharma, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$21.7M
Cash generated from operations
Capital Expenditures
$177.0K
Investment in assets
Dividends
None
No dividend program

CUE SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Cue Biopharma, Inc. (CIK: 0001645460)

📋 Recent SEC Filings

Date Form Document Action
Apr 13, 2026 8-K cue-20260413.htm View →
Apr 10, 2026 4 xslF345X06/ownership.xml View →
Apr 10, 2026 4 xslF345X06/ownership.xml View →
Apr 10, 2026 4 xslF345X06/ownership.xml View →
Apr 7, 2026 8-K cue-20260401.htm View →

Frequently Asked Questions about CUE

What is the AI rating for CUE?

Cue Biopharma, Inc. (CUE) has a Combined AI Rating of SELL from Claude (SELL) and ChatGPT (SELL) with 84% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are CUE's key strengths?

Claude: Strong liquidity position with $27.1M cash and 2.74x current ratio providing near-term operational flexibility. Dramatic 7,793% revenue growth suggests early commercialization or partnerships beginning to generate income. ChatGPT: Strong liquidity with $27.14M in cash and a 2.74x current ratio. No long-term debt, which reduces balance-sheet risk.

What are the risks of investing in CUE?

Claude: Severe cash burn of -$21.9M free cash flow with only 14 months of runway at current burn rate before insolvency. Operating margin of -96.7% and net margin of -96.9% indicate fundamental unprofitability and no path to profitability visible. ChatGPT: Operating and net margins remain near -97%, showing severe unprofitability. Free cash flow of -$21.86M indicates continued heavy cash burn.

What is CUE's revenue and growth?

Cue Biopharma, Inc. reported revenue of $27.5M.

Does CUE pay dividends?

Cue Biopharma, Inc. does not currently pay dividends.

Where can I find CUE SEC filings?

Official SEC filings for Cue Biopharma, Inc. (CIK: 0001645460) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is CUE's EPS?

Cue Biopharma, Inc. has a diluted EPS of $-0.28.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is CUE a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Cue Biopharma, Inc. has a SELL rating with 84% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is CUE stock overvalued or undervalued?

Valuation metrics for CUE: ROE of -100.6% (sector avg: 15%), net margin of -96.9% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy CUE stock in 2026?

Our dual AI analysis gives Cue Biopharma, Inc. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is CUE's free cash flow?

Cue Biopharma, Inc.'s operating cash flow is $-21.7M, with capital expenditures of $177.0K. FCF margin is -79.6%.

How does CUE compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -96.9% (avg: 12%), ROE -100.6% (avg: 15%), current ratio 2.74 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 23, 2026 | Data as of: 2025-12-31 | Powered by Claude AI