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CytomX Therapeutics, Inc. (CTMX) Stock Fundamental Analysis & AI Rating 2026

CTMX Nasdaq Pharmaceutical Preparations DE CIK: 0001501989
Updated This Month • Analysis: Mar 23, 2026 • SEC Data: 2025-12-31
Combined AI Rating
STRONG SELL
87% Confidence
STRONG AGREEMENT
STRONG SELL
85% Conf
STRONG SELL
89% Conf

📊 CTMX Key Takeaways

Revenue: $76.2M
Net Margin: -22.8%
Free Cash Flow: $-75.8M
Current Ratio: 3.09x
Debt/Equity: 0.02x
EPS: $0.00
AI Rating: STRONG SELL with 85% confidence
CytomX Therapeutics, Inc. (CTMX) receives a STRONG SELL rating with 87% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $76.2M, net profit margin of -22.8%, and return on equity (ROE) of -17.5%, CytomX Therapeutics, Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete CTMX stock analysis for 2026.

Is CytomX Therapeutics, Inc. (CTMX) a Good Investment?

Claude

CytomX Therapeutics exhibits severe financial distress with negative net income of -$17.4M despite $76.2M in revenue, indicating fundamental operational unprofitability in the pharmaceutical sector. The company is burning cash at an alarming rate with -$75.8M free cash flow, and at current cash levels ($12.7M) faces a critical runway crisis within months without significant capital raises or operational turnaround.

ChatGPT

CytomX Therapeutics shows weak fundamental quality: revenue was flat, operating margins remain deeply negative, and free cash flow was severely negative relative to revenue. While the balance sheet is lightly levered and current liquidity ratios look healthy on paper, the cash balance is very small relative to the scale of annual operating cash burn, creating significant financing risk unless operating performance improves materially.

Why Buy CytomX Therapeutics, Inc. Stock? CTMX Key Strengths

Claude
  • + Strong liquidity position with 3.09x current ratio providing near-term operational flexibility
  • + Low leverage with 0.02x debt-to-equity ratio minimizing financial distress from debt obligations
  • + Flat revenue maintenance at $76.2M suggests some stability in core business despite unprofitability
ChatGPT
  • + Low leverage with debt/equity of 0.02x limits balance-sheet strain
  • + Current and quick ratios of 3.09x indicate acceptable near-term balance-sheet liquidity
  • + Net loss improved year over year, suggesting some expense discipline or non-operating improvement

CTMX Stock Risks: CytomX Therapeutics, Inc. Investment Risks

Claude
  • ! Catastrophic operating cash burn of -$75.6M annually with only $12.7M cash reserves indicates potential insolvency within 2 months without external funding
  • ! Persistent negative net margins of -22.8% and operating margins of -29.3% demonstrate structural unprofitability across the business model
  • ! Operating income deterioration with -$22.4M loss despite revenue stability indicates inability to scale operations profitably or control costs effectively
ChatGPT
  • ! Operating cash flow of -$75.59M versus only $12.67M in cash implies a very short cash runway
  • ! Revenue growth of 0.0% indicates weak top-line momentum and poor growth quality
  • ! Negative operating margin, net margin, ROE, and ROA show the business remains structurally unprofitable

Key Metrics to Watch

Claude
  • * Operating cash flow trajectory and monthly burn rate to assess runway duration
  • * Revenue growth acceleration and cost structure improvements to achieve positive operating leverage
  • * Cash balance and availability of financing or partnership deals to address immediate liquidity crisis
ChatGPT
  • * Quarterly operating cash burn relative to cash and equivalents
  • * Revenue growth and operating margin improvement

CytomX Therapeutics, Inc. (CTMX) Financial Metrics & Key Ratios

Revenue
$76.2M
Net Income
$-17.4M
EPS (Diluted)
$0.00
Free Cash Flow
$-75.8M
Total Assets
$151.6M
Cash Position
$12.7M

💡 AI Analyst Insight

Strong liquidity with a 3.09x current ratio provides a solid financial cushion.

CTMX Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -29.3%
Net Margin -22.8%
ROE -17.5%
ROA -11.5%
FCF Margin -99.5%

CTMX vs Healthcare Sector: How CytomX Therapeutics, Inc. Compares

How CytomX Therapeutics, Inc. compares to Healthcare sector averages

Net Margin
CTMX -22.8%
vs
Sector Avg 12.0%
CTMX Sector
ROE
CTMX -17.5%
vs
Sector Avg 15.0%
CTMX Sector
Current Ratio
CTMX 3.1x
vs
Sector Avg 2.0x
CTMX Sector
Debt/Equity
CTMX 0.0x
vs
Sector Avg 0.6x
CTMX Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is CytomX Therapeutics, Inc. Stock Overvalued? CTMX Valuation Analysis 2026

Based on fundamental analysis, CytomX Therapeutics, Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-17.5%
Sector avg: 15%
Net Profit Margin
-22.8%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.02x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

CytomX Therapeutics, Inc. Balance Sheet: CTMX Debt, Cash & Liquidity

Current Ratio
3.09x
Quick Ratio
3.09x
Debt/Equity
0.02x
Debt/Assets
34.7%
Interest Coverage
-108.56x
Long-term Debt
$1.6M

CTMX Revenue & Earnings Growth: 5-Year Financial Trend

CTMX 5-year financial data: Year 2021: Revenue $100.4M, Net Income -$102.2M, EPS N/A. Year 2022: Revenue $53.2M, Net Income -$115.9M, EPS $-1.81. Year 2023: Revenue $101.2M, Net Income -$99.3M, EPS $-1.51. Year 2024: Revenue $138.1M, Net Income -$569.0K, EPS $-0.01. Year 2025: Revenue $138.1M, Net Income $31.9M, EPS $0.38.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: CytomX Therapeutics, Inc.'s revenue has grown significantly by 38% over the 5-year period, indicating strong business expansion. The most recent EPS of $0.38 reflects profitable operations.

CTMX Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-99.5%
Free cash flow / Revenue

CTMX Quarterly Earnings & Performance

Quarterly financial performance data for CytomX Therapeutics, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $6.0M -$154.0K $0.07
Q2 2025 $18.7M -$154.0K $0.00
Q1 2025 $41.5M $13.8M $0.17
Q3 2024 $26.4M -$1.1M $-0.02
Q2 2024 $24.7M -$1.1M $-0.02
Q1 2024 $23.5M -$3.3M $-0.05
Q3 2023 $11.1M -$1.1M $-0.02
Q2 2023 $12.9M -$1.1M $-0.02

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

CytomX Therapeutics, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$75.6M
Cash generated from operations
Capital Expenditures
$220.0K
Investment in assets
Dividends
None
No dividend program

CTMX SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for CytomX Therapeutics, Inc. (CIK: 0001501989)

📋 Recent SEC Filings

Date Form Document Action
Mar 19, 2026 4 xslF345X06/form4.xml View →
Mar 19, 2026 4 xslF345X06/form4.xml View →
Mar 19, 2026 4 xslF345X06/form4.xml View →
Mar 19, 2026 4 xslF345X06/form4.xml View →
Mar 19, 2026 8-K d100765d8k.htm View →

Frequently Asked Questions about CTMX

What is the AI rating for CTMX?

CytomX Therapeutics, Inc. (CTMX) has a Combined AI Rating of STRONG SELL from Claude (STRONG SELL) and ChatGPT (STRONG SELL) with 87% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are CTMX's key strengths?

Claude: Strong liquidity position with 3.09x current ratio providing near-term operational flexibility. Low leverage with 0.02x debt-to-equity ratio minimizing financial distress from debt obligations. ChatGPT: Low leverage with debt/equity of 0.02x limits balance-sheet strain. Current and quick ratios of 3.09x indicate acceptable near-term balance-sheet liquidity.

What are the risks of investing in CTMX?

Claude: Catastrophic operating cash burn of -$75.6M annually with only $12.7M cash reserves indicates potential insolvency within 2 months without external funding. Persistent negative net margins of -22.8% and operating margins of -29.3% demonstrate structural unprofitability across the business model. ChatGPT: Operating cash flow of -$75.59M versus only $12.67M in cash implies a very short cash runway. Revenue growth of 0.0% indicates weak top-line momentum and poor growth quality.

What is CTMX's revenue and growth?

CytomX Therapeutics, Inc. reported revenue of $76.2M.

Does CTMX pay dividends?

CytomX Therapeutics, Inc. does not currently pay dividends.

Where can I find CTMX SEC filings?

Official SEC filings for CytomX Therapeutics, Inc. (CIK: 0001501989) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is CTMX's EPS?

CytomX Therapeutics, Inc. has a diluted EPS of $0.00.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is CTMX a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, CytomX Therapeutics, Inc. has a STRONG SELL rating with 87% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is CTMX stock overvalued or undervalued?

Valuation metrics for CTMX: ROE of -17.5% (sector avg: 15%), net margin of -22.8% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy CTMX stock in 2026?

Our dual AI analysis gives CytomX Therapeutics, Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is CTMX's free cash flow?

CytomX Therapeutics, Inc.'s operating cash flow is $-75.6M, with capital expenditures of $220.0K. FCF margin is -99.5%.

How does CTMX compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -22.8% (avg: 12%), ROE -17.5% (avg: 15%), current ratio 3.09 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 23, 2026 | Data as of: 2025-12-31 | Powered by Claude AI