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Assembly Biosciences, Inc.. (ASMB) Stock Fundamental Analysis & AI Rating 2026

ASMB Nasdaq Pharmaceutical Preparations DE CIK: 0001426800
Updated This Month • Analysis: Mar 20, 2026 • SEC Data: 2025-12-31
Combined AI Rating
SELL
75% Confidence
AGREEMENT
SELL
78% Conf
HOLD
72% Conf

📊 ASMB Key Takeaways

Revenue: $72.3M
Net Margin: -8.5%
Free Cash Flow: $-41.2M
Current Ratio: 5.22x
Debt/Equity: 0.00x
EPS: $-0.55
AI Rating: SELL with 78% confidence
Assembly Biosciences, Inc.. (ASMB) receives a SELL rating with 75% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $72.3M, net profit margin of -8.5%, and return on equity (ROE) of -3.0%, Assembly Biosciences, Inc.. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ASMB stock analysis for 2026.

Is Assembly Biosciences, Inc.. (ASMB) a Good Investment?

Claude

Assembly Biosciences demonstrates strong revenue growth (+153.5% YoY) but is burning significant cash with negative operating income, negative free cash flow of -$41.2M, and deteriorating profitability metrics. Despite a solid balance sheet with $58.5M in cash and low debt, the company's current cash burn rate is unsustainable and threatens long-term viability without achieving profitability or securing additional funding.

ChatGPT

Assembly Biosciences shows a materially improved top line, with revenue up 153.5% year over year, while maintaining a strong balance sheet with no meaningful leverage and ample near-term liquidity. However, the business remains unprofitable, free cash flow is deeply negative, and the quality and durability of revenue growth appear less proven than the headline growth rate suggests. Fundamentally, this looks like a well-financed but still cash-burning development-stage biotech rather than a consistently self-sustaining operating business.

Why Buy Assembly Biosciences, Inc.. Stock? ASMB Key Strengths

Claude
  • + Exceptional revenue growth of 153.5% year-over-year indicates strong commercial traction or successful product launches
  • + Strong balance sheet with $58.5M in cash, $206.8M stockholders' equity, and minimal debt (0.00x debt-to-equity ratio)
  • + High liquidity with current ratio of 5.22x provides runway to weather operational challenges
ChatGPT
  • + Very strong liquidity with a 5.22x current ratio and $58.45M in cash
  • + Debt-free capital structure reduces financial risk and preserves flexibility
  • + Revenue growth was exceptionally strong year over year, indicating meaningful business progress

ASMB Stock Risks: Assembly Biosciences, Inc.. Investment Risks

Claude
  • ! Severe cash burn of -$41.1M in operating cash flow with negative free cash flow margin of -56.9%, indicating revenue growth is not translating to profitability
  • ! Operating margin of -16.8% and net margin of -8.5% show the company is not yet profitable despite substantial revenue, suggesting unsustainable cost structure
  • ! Continued negative operating cash flow at current burn rate would exhaust cash reserves within approximately 1.4 years without achieving profitability or securing additional capital
ChatGPT
  • ! The company remains unprofitable with negative operating and net margins
  • ! Operating cash flow and free cash flow are significantly negative, implying continued cash burn
  • ! Revenue durability may be weak if growth is driven by milestone or collaboration payments rather than recurring commercial sales

Key Metrics to Watch

Claude
  • * Path to operating profitability and operating margin expansion
  • * Operating cash flow trend and time to cash flow breakeven
  • * Cash burn rate and runway remaining at current burn levels
  • * Gross margin sustainability as revenue scales
ChatGPT
  • * Quarterly operating cash burn relative to cash balance
  • * Revenue mix and repeatability, especially whether growth converts into sustained operating margin improvement

Assembly Biosciences, Inc.. (ASMB) Financial Metrics & Key Ratios

Revenue
$72.3M
Net Income
$-6.1M
EPS (Diluted)
$-0.55
Free Cash Flow
$-41.2M
Total Assets
$257.6M
Cash Position
$58.5M

💡 AI Analyst Insight

Strong liquidity with a 5.22x current ratio provides a solid financial cushion.

ASMB Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -16.8%
Net Margin -8.5%
ROE -3.0%
ROA -2.4%
FCF Margin -56.9%

ASMB vs Healthcare Sector: How Assembly Biosciences, Inc.. Compares

How Assembly Biosciences, Inc.. compares to Healthcare sector averages

Net Margin
ASMB -8.5%
vs
Sector Avg 12.0%
ASMB Sector
ROE
ASMB -3.0%
vs
Sector Avg 15.0%
ASMB Sector
Current Ratio
ASMB 5.2x
vs
Sector Avg 2.0x
ASMB Sector
Debt/Equity
ASMB 0.0x
vs
Sector Avg 0.6x
ASMB Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Assembly Biosciences, Inc.. Stock Overvalued? ASMB Valuation Analysis 2026

Based on fundamental analysis, Assembly Biosciences, Inc.. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-3.0%
Sector avg: 15%
Net Profit Margin
-8.5%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Assembly Biosciences, Inc.. Balance Sheet: ASMB Debt, Cash & Liquidity

Current Ratio
5.22x
Quick Ratio
5.22x
Debt/Equity
0.00x
Debt/Assets
19.7%
Interest Coverage
-0.87x
Long-term Debt
N/A

ASMB Revenue & Earnings Growth: 5-Year Financial Trend

ASMB 5-year financial data: Year 2025: Revenue $72.3M, Net Income -$40.2M, EPS $-6.69.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Assembly Biosciences, Inc..'s revenue has remained relatively flat over the 5-year period, with a 0% decline. The most recent EPS of $-6.69 indicates the company is currently unprofitable.

ASMB Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-56.9%
Free cash flow / Revenue

ASMB Quarterly Earnings & Performance

Quarterly financial performance data for Assembly Biosciences, Inc.. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $6.8M -$9.2M $-0.72
Q2 2025 $8.5M -$10.2M $-1.33
Q1 2025 $5.8M -$8.8M $-1.17
Q3 2024 N/A -$9.6M $-1.51
Q2 2024 N/A -$11.2M $-1.98
Q1 2024 N/A -$9.1M $-1.66
Q3 2022 $6.3M -$18.8M $-0.41
Q3 2021 $6.3M -$3.3M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Assembly Biosciences, Inc.. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$41.1M
Cash generated from operations
Capital Expenditures
$66.0K
Investment in assets
Dividends
None
No dividend program

ASMB SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Assembly Biosciences, Inc.. (CIK: 0001426800)

📋 Recent SEC Filings

Date Form Document Action
Mar 31, 2026 4 xslF345X06/ownership.xml View →
Mar 31, 2026 4 xslF345X06/ownership.xml View →
Mar 31, 2026 4 xslF345X06/ownership.xml View →
Mar 31, 2026 4 xslF345X06/ownership.xml View →
Mar 31, 2026 4 xslF345X06/ownership.xml View →

Frequently Asked Questions about ASMB

What is the AI rating for ASMB?

Assembly Biosciences, Inc.. (ASMB) has a Combined AI Rating of SELL from Claude (SELL) and ChatGPT (HOLD) with 75% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are ASMB's key strengths?

Claude: Exceptional revenue growth of 153.5% year-over-year indicates strong commercial traction or successful product launches. Strong balance sheet with $58.5M in cash, $206.8M stockholders' equity, and minimal debt (0.00x debt-to-equity ratio). ChatGPT: Very strong liquidity with a 5.22x current ratio and $58.45M in cash. Debt-free capital structure reduces financial risk and preserves flexibility.

What are the risks of investing in ASMB?

Claude: Severe cash burn of -$41.1M in operating cash flow with negative free cash flow margin of -56.9%, indicating revenue growth is not translating to profitability. Operating margin of -16.8% and net margin of -8.5% show the company is not yet profitable despite substantial revenue, suggesting unsustainable cost structure. ChatGPT: The company remains unprofitable with negative operating and net margins. Operating cash flow and free cash flow are significantly negative, implying continued cash burn.

What is ASMB's revenue and growth?

Assembly Biosciences, Inc.. reported revenue of $72.3M.

Does ASMB pay dividends?

Assembly Biosciences, Inc.. does not currently pay dividends.

Where can I find ASMB SEC filings?

Official SEC filings for Assembly Biosciences, Inc.. (CIK: 0001426800) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ASMB's EPS?

Assembly Biosciences, Inc.. has a diluted EPS of $-0.55.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is ASMB a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Assembly Biosciences, Inc.. has a SELL rating with 75% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is ASMB stock overvalued or undervalued?

Valuation metrics for ASMB: ROE of -3.0% (sector avg: 15%), net margin of -8.5% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy ASMB stock in 2026?

Our dual AI analysis gives Assembly Biosciences, Inc.. a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ASMB's free cash flow?

Assembly Biosciences, Inc..'s operating cash flow is $-41.1M, with capital expenditures of $66.0K. FCF margin is -56.9%.

How does ASMB compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -8.5% (avg: 12%), ROE -3.0% (avg: 15%), current ratio 5.22 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 20, 2026 | Data as of: 2025-12-31 | Powered by Claude AI