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Aptevo Therapeutics Inc. (APVO) Stock Fundamental Analysis & AI Rating 2026

APVO Nasdaq Pharmaceutical Preparations DE CIK: 0001671584
Updated This Month • Analysis: Mar 20, 2026 • SEC Data: 2025-09-30
Combined AI Rating
STRONG SELL
93% Confidence
STRONG AGREEMENT
STRONG SELL
92% Conf
STRONG SELL
94% Conf

📊 APVO Key Takeaways

Revenue: $3.1M
Net Margin: -647.4%
Free Cash Flow: $-20.4M
Current Ratio: 4.03x
Debt/Equity: 0.00x
EPS: $-11.42
AI Rating: STRONG SELL with 92% confidence
Aptevo Therapeutics Inc. (APVO) receives a STRONG SELL rating with 93% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $3.1M, net profit margin of -647.4%, and return on equity (ROE) of -115.9%, Aptevo Therapeutics Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete APVO stock analysis for 2026.

Is Aptevo Therapeutics Inc. (APVO) a Good Investment?

Claude

Aptevo Therapeutics is in severe financial distress with collapsing revenue (-74.7% YoY), massive operating losses (-$20.3M on only $3.1M revenue), and negative free cash flow of -$20.4M. Despite adequate liquidity, the company is burning cash at an unsustainable rate with no clear path to profitability, characteristic of a pre-revenue or failed-asset biotech with fundamental business viability concerns.

ChatGPT

Aptevo Therapeutics shows very weak fundamentals, with revenue down 74.7% year over year and extremely negative operating and net margins, indicating the business is not currently converting its pipeline or collaborations into sustainable income. While the balance sheet has low leverage and meaningful cash relative to liabilities, the company is burning over $20M in annual operating cash flow against only $21.06M of cash, creating significant funding and dilution risk unless operating performance improves materially.

Why Buy Aptevo Therapeutics Inc. Stock? APVO Key Strengths

Claude
  • + Strong current ratio of 4.03x provides near-term liquidity runway
  • + Zero long-term debt eliminates bankruptcy risk from leverage
  • + Maintains $21.1M cash balance for operational continuity in short-term
ChatGPT
  • + Strong liquidity profile with a 4.03x current ratio and no long-term debt
  • + Cash balance of $21.06M exceeds total liabilities of $9.60M, providing short-term financial flexibility
  • + Positive equity base of $17.39M supports balance sheet stability relative to many distressed biotech peers

APVO Stock Risks: Aptevo Therapeutics Inc. Investment Risks

Claude
  • ! Revenue collapse of 74.7% YoY indicates loss of commercial traction or product failure
  • ! Operating burn rate of $20.3M annually with only $3.1M revenue is unsustainable
  • ! Negative free cash flow of -$20.4M will deplete $21.1M cash within ~12 months at current burn rate
  • ! Severely negative margins (operating -652%, net -647%) indicate no viable business model
  • ! Pharmaceutical sector with failed commercial execution faces high risk of total equity loss
ChatGPT
  • ! Revenue collapsed 74.7% year over year, signaling poor growth quality and unstable commercialization or collaboration income
  • ! Operating loss of $20.32M and free cash flow of -$20.39M indicate an unsustainable cash burn rate
  • ! Severely negative profitability metrics, including -652.4% operating margin and -115.9% ROE, reflect weak business economics

Key Metrics to Watch

Claude
  • * Quarterly revenue trend - any stabilization or further deterioration
  • * Cash burn rate and runway months - critical given current trajectory
  • * Operating expense reduction initiatives - cost control measures
  • * Quarterly operating cash flow - whether negative trends persist
  • * Any new partnership, licensing, or asset sale announcements
ChatGPT
  • * Quarterly cash burn versus cash and equivalents
  • * Revenue trajectory and any improvement in operating loss

Aptevo Therapeutics Inc. (APVO) Financial Metrics & Key Ratios

Revenue
$3.1M
Net Income
$-20.2M
EPS (Diluted)
$-11.42
Free Cash Flow
$-20.4M
Total Assets
$27.0M
Cash Position
$21.1M

💡 AI Analyst Insight

Strong liquidity with a 4.03x current ratio provides a solid financial cushion.

APVO Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -652.4%
Net Margin -647.4%
ROE -115.9%
ROA -74.7%
FCF Margin -654.6%

APVO vs Healthcare Sector: How Aptevo Therapeutics Inc. Compares

How Aptevo Therapeutics Inc. compares to Healthcare sector averages

Net Margin
APVO -647.4%
vs
Sector Avg 12.0%
APVO Sector
ROE
APVO -115.9%
vs
Sector Avg 15.0%
APVO Sector
Current Ratio
APVO 4.0x
vs
Sector Avg 2.0x
APVO Sector
Debt/Equity
APVO 0.0x
vs
Sector Avg 0.6x
APVO Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Aptevo Therapeutics Inc. Stock Overvalued? APVO Valuation Analysis 2026

Based on fundamental analysis, Aptevo Therapeutics Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-115.9%
Sector avg: 15%
Net Profit Margin
-647.4%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Aptevo Therapeutics Inc. Balance Sheet: APVO Debt, Cash & Liquidity

Current Ratio
4.03x
Quick Ratio
2.94x
Debt/Equity
0.00x
Debt/Assets
35.6%
Interest Coverage
N/A
Long-term Debt
$0.0

APVO Revenue & Earnings Growth: 5-Year Financial Trend

APVO 5-year financial data: Year 2019: Revenue $32.4M, Net Income N/A, EPS N/A. Year 2020: Revenue $4.3M, Net Income N/A, EPS N/A. Year 2021: Revenue $12.3M, Net Income -$17.8M, EPS N/A. Year 2022: Revenue $12.3M, Net Income -$28.5M, EPS $-6.07. Year 2023: Revenue $3.1M, Net Income $8.0M, EPS $1.57.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Aptevo Therapeutics Inc.'s revenue has declined by 90% over the 5-year period, indicating business contraction. The most recent EPS of $-31,460.23 indicates the company is currently unprofitable.

APVO Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-654.6%
Free cash flow / Revenue

APVO Quarterly Earnings & Performance

Quarterly financial performance data for Aptevo Therapeutics Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2023 $3.1M $2.8M $-0.50
Q2 2023 $3.1M $2.8M $-0.72
Q1 2023 $3.1M $2.8M $0.26
Q3 2022 $3.1M -$7.0M $-1.43
Q2 2022 $3.1M -$7.3M $-1.75
Q1 2022 $2.4M -$7.3M N/A
Q3 2021 $1.5M $2.9M N/A
Q2 2021 $473.0K $2.9M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Aptevo Therapeutics Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$20.4M
Cash generated from operations
Capital Expenditures
$29.0K
Investment in assets
Dividends
None
No dividend program

APVO SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Aptevo Therapeutics Inc. (CIK: 0001671584)

📋 Recent SEC Filings

Date Form Document Action
Mar 26, 2026 10-K apvo-20251231.htm View →
Mar 26, 2026 8-K apvo-20260326.htm View →
Mar 11, 2026 8-K apvo-20260310.htm View →
Feb 19, 2026 8-K apvo-20260218.htm View →
Feb 3, 2026 8-K apvo-20260130.htm View →

Frequently Asked Questions about APVO

What is the AI rating for APVO?

Aptevo Therapeutics Inc. (APVO) has a Combined AI Rating of STRONG SELL from Claude (STRONG SELL) and ChatGPT (STRONG SELL) with 93% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are APVO's key strengths?

Claude: Strong current ratio of 4.03x provides near-term liquidity runway. Zero long-term debt eliminates bankruptcy risk from leverage. ChatGPT: Strong liquidity profile with a 4.03x current ratio and no long-term debt. Cash balance of $21.06M exceeds total liabilities of $9.60M, providing short-term financial flexibility.

What are the risks of investing in APVO?

Claude: Revenue collapse of 74.7% YoY indicates loss of commercial traction or product failure. Operating burn rate of $20.3M annually with only $3.1M revenue is unsustainable. ChatGPT: Revenue collapsed 74.7% year over year, signaling poor growth quality and unstable commercialization or collaboration income. Operating loss of $20.32M and free cash flow of -$20.39M indicate an unsustainable cash burn rate.

What is APVO's revenue and growth?

Aptevo Therapeutics Inc. reported revenue of $3.1M.

Does APVO pay dividends?

Aptevo Therapeutics Inc. does not currently pay dividends.

Where can I find APVO SEC filings?

Official SEC filings for Aptevo Therapeutics Inc. (CIK: 0001671584) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is APVO's EPS?

Aptevo Therapeutics Inc. has a diluted EPS of $-11.42.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is APVO a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Aptevo Therapeutics Inc. has a STRONG SELL rating with 93% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is APVO stock overvalued or undervalued?

Valuation metrics for APVO: ROE of -115.9% (sector avg: 15%), net margin of -647.4% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy APVO stock in 2026?

Our dual AI analysis gives Aptevo Therapeutics Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is APVO's free cash flow?

Aptevo Therapeutics Inc.'s operating cash flow is $-20.4M, with capital expenditures of $29.0K. FCF margin is -654.6%.

How does APVO compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -647.4% (avg: 12%), ROE -115.9% (avg: 15%), current ratio 4.03 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 20, 2026 | Data as of: 2025-09-30 | Powered by Claude AI