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Alx Oncology Holdings Inc. (ALXO) Stock Fundamental Analysis & AI Rating 2026

ALXO Nasdaq Pharmaceutical Preparations DE CIK: 0001810182
Updated This Month • Analysis: Mar 19, 2026 • SEC Data: 2025-12-31
Combined AI Rating
STRONG SELL
90% Confidence
STRONG AGREEMENT
STRONG SELL
92% Conf
STRONG SELL
88% Conf

📊 ALXO Key Takeaways

Revenue: $0.0
Net Margin: N/A
Free Cash Flow: $-84.4M
Current Ratio: 2.07x
Debt/Equity: 0.39x
EPS: $-1.90
AI Rating: STRONG SELL with 92% confidence
Alx Oncology Holdings Inc. (ALXO) receives a STRONG SELL rating with 90% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $0, and return on equity (ROE) of -391.4%, Alx Oncology Holdings Inc. demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ALXO stock analysis for 2026.

Is Alx Oncology Holdings Inc. (ALXO) a Good Investment?

Claude

ALX Oncology is a pre-revenue biotech company with severe cash burn of $84.1M operating cash outflow and only $16.4M in cash reserves, creating acute runway risk. The company is unprofitable with negative operating margins and deteriorating cash position relative to burn rate, with no clear path to revenue generation in the near term.

ChatGPT

ALX Oncology shows very weak fundamentals: no revenue, persistent operating and net losses, and deeply negative operating and free cash flow. While liquidity ratios are still above 2x and debt is not yet extreme relative to assets, the current cash balance appears small versus the annual cash burn, creating meaningful funding and dilution risk unless the business materially improves its clinical and commercial outlook.

Why Buy Alx Oncology Holdings Inc. Stock? ALXO Key Strengths

Claude
  • + Adequate current ratio of 2.07x indicates short-term liquidity sufficient for near-term operations
  • + Moderate debt burden with Debt/Equity of 0.39x suggests manageable leverage relative to equity base
  • + Recent insider activity with 14 Form 4 filings suggests ongoing executive engagement
ChatGPT
  • + Current and quick ratios of 2.07x indicate near-term liabilities are still covered by liquid assets
  • + Debt/equity of 0.39x suggests leverage is not yet the primary balance-sheet problem
  • + Capital expenditure is minimal, which limits additional cash strain from fixed-asset investment

ALXO Stock Risks: Alx Oncology Holdings Inc. Investment Risks

Claude
  • ! Zero revenue with $104M operating loss indicates failed or stalled drug development programs
  • ! Critical cash runway concern: $16.4M cash against $84.1M annual burn rate represents less than 2.5 months of operations
  • ! Severe profitability metrics with ROE of -391.4% and ROA of -172.2% demonstrate value destruction
  • ! Negative $84.4M free cash flow with no offsetting revenue generation creates imminent solvency risk
  • ! Operating cash outflow increasing relative to prior period suggests accelerating cash depletion without progress toward commercialization
ChatGPT
  • ! Zero revenue means the business currently lacks a proven commercial engine
  • ! Operating cash flow of -$84.14M and free cash flow of -$84.35M imply an unsustainable cash burn relative to $16.37M cash
  • ! ROE of -391.4% and ROA of -172.2% reflect severe capital destruction and weak asset productivity

Key Metrics to Watch

Claude
  • * Monthly cash burn rate and remaining cash runway
  • * Clinical trial progress updates and regulatory milestones for pipeline assets
  • * Any revenue generation or partnership announcements from drug candidates
  • * Quarterly operating cash flow trend and burn trajectory
  • * Equity financing activities and dilution risk from future capital raises
ChatGPT
  • * Cash runway relative to quarterly operating cash burn
  • * Any transition from zero revenue toward recurring product or collaboration revenue

Alx Oncology Holdings Inc. (ALXO) Financial Metrics & Key Ratios

Revenue
$0.0
Net Income
$-101.7M
EPS (Diluted)
$-1.90
Free Cash Flow
$-84.4M
Total Assets
$59.0M
Cash Position
$16.4M

💡 AI Analyst Insight

Strong liquidity with a 2.07x current ratio provides a solid financial cushion.

ALXO Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin N/A
Net Margin N/A
ROE -391.4%
ROA -172.2%
FCF Margin N/A

ALXO vs Healthcare Sector: How Alx Oncology Holdings Inc. Compares

How Alx Oncology Holdings Inc. compares to Healthcare sector averages

Net Margin
ALXO 0.0%
vs
Sector Avg 12.0%
ALXO Sector
ROE
ALXO -391.4%
vs
Sector Avg 15.0%
ALXO Sector
Current Ratio
ALXO 2.1x
vs
Sector Avg 2.0x
ALXO Sector
Debt/Equity
ALXO 0.4x
vs
Sector Avg 0.6x
ALXO Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Alx Oncology Holdings Inc. Stock Overvalued? ALXO Valuation Analysis 2026

Based on fundamental analysis, Alx Oncology Holdings Inc. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-391.4%
Sector avg: 15%
Net Profit Margin
N/A
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.39x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Alx Oncology Holdings Inc. Balance Sheet: ALXO Debt, Cash & Liquidity

Current Ratio
2.07x
Quick Ratio
2.07x
Debt/Equity
0.39x
Debt/Assets
56.0%
Interest Coverage
-64.93x
Long-term Debt
$10.2M

ALXO Revenue & Earnings Growth: 5-Year Financial Trend

ALXO 5-year financial data: Year 2020: Revenue $4.8M, Net Income N/A, EPS N/A. Year 2021: Revenue $4.8M, Net Income -$19.2M, EPS N/A. Year 2022: Revenue $1.2M, Net Income -$45.7M, EPS $-2.76.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Alx Oncology Holdings Inc.'s revenue has declined by 75% over the 5-year period, indicating business contraction. The most recent EPS of $-3.74 indicates the company is currently unprofitable.

ALXO Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
N/A
Free cash flow / Revenue

ALXO Quarterly Earnings & Performance

Quarterly financial performance data for Alx Oncology Holdings Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2021 $1.2M -$10.2M N/A
Q2 2021 $527.0K -$5.5M N/A
Q1 2021 $655.0K -$5.5M N/A
Q3 2020 $1.2M -$3.0M N/A
Q2 2020 $527.0K -$4.2M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Alx Oncology Holdings Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$84.1M
Cash generated from operations
Stock Buybacks
$6.0K
Shares repurchased (TTM)
Capital Expenditures
$212.0K
Investment in assets
Dividends
None
No dividend program

ALXO SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Alx Oncology Holdings Inc. (CIK: 0001810182)

📋 Recent SEC Filings

Date Form Document Action
Apr 13, 2026 8-K alxo-20260413.htm View →
Mar 23, 2026 4 xslF345X06/ownership.xml View →
Mar 23, 2026 4 xslF345X06/ownership.xml View →
Mar 9, 2026 10-K alxo-20251231.htm View →
Mar 5, 2026 4 xslF345X05/ownership.xml View →

Frequently Asked Questions about ALXO

What is the AI rating for ALXO?

Alx Oncology Holdings Inc. (ALXO) has a Combined AI Rating of STRONG SELL from Claude (STRONG SELL) and ChatGPT (STRONG SELL) with 90% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are ALXO's key strengths?

Claude: Adequate current ratio of 2.07x indicates short-term liquidity sufficient for near-term operations. Moderate debt burden with Debt/Equity of 0.39x suggests manageable leverage relative to equity base. ChatGPT: Current and quick ratios of 2.07x indicate near-term liabilities are still covered by liquid assets. Debt/equity of 0.39x suggests leverage is not yet the primary balance-sheet problem.

What are the risks of investing in ALXO?

Claude: Zero revenue with $104M operating loss indicates failed or stalled drug development programs. Critical cash runway concern: $16.4M cash against $84.1M annual burn rate represents less than 2.5 months of operations. ChatGPT: Zero revenue means the business currently lacks a proven commercial engine. Operating cash flow of -$84.14M and free cash flow of -$84.35M imply an unsustainable cash burn relative to $16.37M cash.

What is ALXO's revenue and growth?

Alx Oncology Holdings Inc. reported revenue of $0.0.

Does ALXO pay dividends?

Alx Oncology Holdings Inc. does not currently pay dividends.

Where can I find ALXO SEC filings?

Official SEC filings for Alx Oncology Holdings Inc. (CIK: 0001810182) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ALXO's EPS?

Alx Oncology Holdings Inc. has a diluted EPS of $-1.90.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is ALXO a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Alx Oncology Holdings Inc. has a STRONG SELL rating with 90% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is ALXO stock overvalued or undervalued?

Valuation metrics for ALXO: ROE of -391.4% (sector avg: 15%), net margin of N/A (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy ALXO stock in 2026?

Our dual AI analysis gives Alx Oncology Holdings Inc. a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ALXO's free cash flow?

Alx Oncology Holdings Inc.'s operating cash flow is $-84.1M, with capital expenditures of $212.0K.

How does ALXO compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin N/A (avg: 12%), ROE -391.4% (avg: 15%), current ratio 2.07 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 19, 2026 | Data as of: 2025-12-31 | Powered by Claude AI