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Alnylam Pharmaceuticals, Inc.. (ALNY) Stock Fundamental Analysis & AI Rating 2026

ALNY Nasdaq Pharmaceutical Preparations CIK: 0001178670
Updated This Month • Analysis: Mar 19, 2026 • SEC Data: 2025-12-31
Combined AI Rating
BUY
82% Confidence
AGREEMENT
STRONG BUY
85% Conf
BUY
78% Conf

📊 ALNY Key Takeaways

Revenue: $3.7B
Net Margin: 8.4%
Free Cash Flow: $465.4M
Current Ratio: 2.76x
Debt/Equity: 0.86x
EPS: $2.33
AI Rating: STRONG BUY with 85% confidence
Alnylam Pharmaceuticals, Inc.. (ALNY) receives a BUY rating with 82% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $3.7B, net profit margin of 8.4%, and return on equity (ROE) of 39.8%, Alnylam Pharmaceuticals, Inc.. demonstrates strong fundamentals in the Healthcare sector. Below is our complete ALNY stock analysis for 2026.

Is Alnylam Pharmaceuticals, Inc.. (ALNY) a Good Investment?

Claude

Alnylam demonstrates exceptional financial momentum with 65.2% revenue growth, transformative profitability improvements (net income +212.8% YoY), and strong cash generation (FCF of $465.4M). The company exhibits solid financial health with a current ratio of 2.76x, manageable leverage at 0.86x debt-to-equity, and robust interest coverage of 14.2x, positioning it well for sustained growth and operational flexibility.

ChatGPT

Alnylam shows a major step-up in fundamentals, with revenue up 65.2% YoY, net income up 212.8%, and positive free cash flow of $465.38M, indicating that growth is translating into real earnings and cash generation. Liquidity is strong with $1.66B in cash and current and quick ratios above 2.7x, but the balance sheet still carries meaningful liabilities relative to equity, so the core story is strong execution with some balance-sheet sensitivity.

Why Buy Alnylam Pharmaceuticals, Inc.. Stock? ALNY Key Strengths

Claude
  • + Explosive revenue growth of 65.2% YoY indicating strong market traction and demand for pipeline products
  • + Outstanding earnings leverage with net income up 212.8% YoY and net margin of 8.4%, demonstrating significant operational leverage
  • + Healthy balance sheet with $1.7B cash, current ratio of 2.76x, and manageable debt-to-equity ratio of 0.86x
  • + Strong free cash flow generation of $465.4M with 12.5% FCF margin supporting dividend potential and R&D investments
  • + Superior liquidity metrics with quick ratio of 2.71x indicating ability to meet short-term obligations
  • + Exceptional ROE of 39.8% reflecting highly efficient capital deployment
ChatGPT
  • + Revenue growth of 65.2% YoY with net income growth of 212.8% shows accelerating operating leverage
  • + Positive operating cash flow of $524.08M and free cash flow of $465.38M support higher-quality earnings
  • + Strong liquidity profile with $1.66B cash and current ratio of 2.76x reduces near-term funding risk

ALNY Stock Risks: Alnylam Pharmaceuticals, Inc.. Investment Risks

Claude
  • ! Heavy reliance on pharmaceutical revenue with limited gross margin visibility in disclosed data
  • ! Significant insider activity (27 Form 4 filings in 90 days) warrants monitoring for potential concern signals
  • ! Operating margin of 13.5% compressed relative to net margin of 8.4% suggests elevated non-operating expenses or tax burden
  • ! Long-term debt of $677.7M requires ongoing servicing despite strong cash flow generation
  • ! Pharmaceutical sector exposure to regulatory changes, patent cliffs, and competitive pressures
ChatGPT
  • ! Stockholders' equity is relatively low at $789.18M versus $4.18B of liabilities, leaving less balance-sheet cushion
  • ! Net margin of 8.4% and operating margin of 13.5% are improved but still not especially high for a successful pharmaceutical business
  • ! Long-term debt of $677.72M and debt-to-equity of 0.86x warrant monitoring if profitability weakens

Key Metrics to Watch

Claude
  • * Revenue growth sustainability and pipeline approval status
  • * Gross margin trends and product mix evolution
  • * Free cash flow consistency and cash conversion rate
  • * Debt reduction trajectory and leverage ratios
  • * Operating expense management and margin expansion potential
  • * R&D spending efficiency and pipeline advancement
ChatGPT
  • * Operating margin and net margin sustainability
  • * Free cash flow and cash balance relative to debt and liabilities

Alnylam Pharmaceuticals, Inc.. (ALNY) Financial Metrics & Key Ratios

Revenue
$3.7B
Net Income
$313.7M
EPS (Diluted)
$2.33
Free Cash Flow
$465.4M
Total Assets
$5.0B
Cash Position
$1.7B

💡 AI Analyst Insight

Strong liquidity with a 2.76x current ratio provides a solid financial cushion.

ALNY Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin 13.5%
Net Margin 8.4%
ROE 39.8%
ROA 6.3%
FCF Margin 12.5%

ALNY vs Healthcare Sector: How Alnylam Pharmaceuticals, Inc.. Compares

How Alnylam Pharmaceuticals, Inc.. compares to Healthcare sector averages

Net Margin
ALNY 8.4%
vs
Sector Avg 12.0%
ALNY Sector
ROE
ALNY 39.8%
vs
Sector Avg 15.0%
ALNY Sector
Current Ratio
ALNY 2.8x
vs
Sector Avg 2.0x
ALNY Sector
Debt/Equity
ALNY 0.9x
vs
Sector Avg 0.6x
ALNY Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Alnylam Pharmaceuticals, Inc.. Stock Overvalued? ALNY Valuation Analysis 2026

Based on fundamental analysis, Alnylam Pharmaceuticals, Inc.. has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
39.8%
Sector avg: 15%
Net Profit Margin
8.4%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.86x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Alnylam Pharmaceuticals, Inc.. Balance Sheet: ALNY Debt, Cash & Liquidity

Current Ratio
2.76x
Quick Ratio
2.71x
Debt/Equity
0.86x
Debt/Assets
84.1%
Interest Coverage
14.23x
Long-term Debt
$677.7M

ALNY Revenue & Earnings Growth: 5-Year Financial Trend

ALNY 5-year financial data: Year 2019: Revenue $219.8M, Net Income N/A, EPS N/A. Year 2020: Revenue $492.9M, Net Income N/A, EPS N/A. Year 2023: Revenue $1.8B, Net Income -$852.8M, EPS $-7.20. Year 2024: Revenue $2.2B, Net Income -$1.1B, EPS $-9.30. Year 2025: Revenue $3.7B, Net Income -$440.2M, EPS $-3.52.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Alnylam Pharmaceuticals, Inc..'s revenue has grown significantly by 1,590% over the 5-year period, indicating strong business expansion. The most recent EPS of $-3.52 indicates the company is currently unprofitable.

ALNY Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
12.5%
Free cash flow / Revenue

ALNY Quarterly Earnings & Performance

Quarterly financial performance data for Alnylam Pharmaceuticals, Inc.. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $500.9M -$16.9M $-0.87
Q2 2025 $659.8M -$16.9M $-0.13
Q1 2025 $494.3M -$57.5M $-0.44
Q3 2024 $500.9M -$16.9M $-0.87
Q2 2024 $318.8M -$16.9M $-0.13
Q1 2024 $319.3M -$65.9M $-0.52
Q3 2023 $264.3M $147.8M $1.15
Q2 2023 $224.8M -$174.1M $-2.21

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Alnylam Pharmaceuticals, Inc.. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
$524.1M
Cash generated from operations
Capital Expenditures
$58.7M
Investment in assets
Dividends
None
No dividend program

ALNY SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Alnylam Pharmaceuticals, Inc.. (CIK: 0001178670)

📋 Recent SEC Filings

Date Form Document Action
Apr 7, 2026 4 xslF345X06/form4.xml View →
Apr 6, 2026 DEF 14A alny-20260406.htm View →
Mar 6, 2026 4 xslF345X05/edgardoc.xml View →
Mar 6, 2026 4 xslF345X05/edgardoc.xml View →
Mar 6, 2026 4 xslF345X05/edgardoc.xml View →

Frequently Asked Questions about ALNY

What is the AI rating for ALNY?

Alnylam Pharmaceuticals, Inc.. (ALNY) has a Combined AI Rating of BUY from Claude (STRONG BUY) and ChatGPT (BUY) with 82% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are ALNY's key strengths?

Claude: Explosive revenue growth of 65.2% YoY indicating strong market traction and demand for pipeline products. Outstanding earnings leverage with net income up 212.8% YoY and net margin of 8.4%, demonstrating significant operational leverage. ChatGPT: Revenue growth of 65.2% YoY with net income growth of 212.8% shows accelerating operating leverage. Positive operating cash flow of $524.08M and free cash flow of $465.38M support higher-quality earnings.

What are the risks of investing in ALNY?

Claude: Heavy reliance on pharmaceutical revenue with limited gross margin visibility in disclosed data. Significant insider activity (27 Form 4 filings in 90 days) warrants monitoring for potential concern signals. ChatGPT: Stockholders' equity is relatively low at $789.18M versus $4.18B of liabilities, leaving less balance-sheet cushion. Net margin of 8.4% and operating margin of 13.5% are improved but still not especially high for a successful pharmaceutical business.

What is ALNY's revenue and growth?

Alnylam Pharmaceuticals, Inc.. reported revenue of $3.7B.

Does ALNY pay dividends?

Alnylam Pharmaceuticals, Inc.. does not currently pay dividends.

Where can I find ALNY SEC filings?

Official SEC filings for Alnylam Pharmaceuticals, Inc.. (CIK: 0001178670) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ALNY's EPS?

Alnylam Pharmaceuticals, Inc.. has a diluted EPS of $2.33.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is ALNY a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Alnylam Pharmaceuticals, Inc.. has a BUY rating with 82% confidence. The AI analysis suggests favorable fundamentals based on SEC filings. This is not investment advice.

Is ALNY stock overvalued or undervalued?

Valuation metrics for ALNY: ROE of 39.8% (sector avg: 15%), net margin of 8.4% (sector avg: 12%). Higher ROE suggests strong returns relative to peers.

Should I buy ALNY stock in 2026?

Our dual AI analysis gives Alnylam Pharmaceuticals, Inc.. a combined BUY rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ALNY's free cash flow?

Alnylam Pharmaceuticals, Inc..'s operating cash flow is $524.1M, with capital expenditures of $58.7M. FCF margin is 12.5%.

How does ALNY compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin 8.4% (avg: 12%), ROE 39.8% (avg: 15%), current ratio 2.76 (avg: 2).

Why is ALNY's return on equity (ROE) so high?

Alnylam Pharmaceuticals, Inc.. has a return on equity of 39.8%, significantly above the Healthcare sector average of 15%. A high ROE indicates the company is efficient at generating profits from shareholder equity. This is supported by a 8.4% net margin.

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 19, 2026 | Data as of: 2025-12-31 | Powered by Claude AI