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Krystal Biotech, Inc. (KRYS) Stock Fundamental Analysis & AI Rating 2026

KRYS Nasdaq Biological Products, (No Diagnostic Substances) CIK: 0001711279
Recently Updated • Analysis: Apr 12, 2026 • SEC Data: 2025-12-31
Combined AI Rating
BUY
80% Confidence
AGREEMENT
STRONG BUY
77% Conf
BUY
82% Conf

📊 KRYS Key Takeaways

Revenue: $389.1M
Net Margin: 52.6%
Free Cash Flow: $188.9M
Current Ratio: 9.95x
Debt/Equity: 0.00x
EPS: $6.84
AI Rating: STRONG BUY with 77% confidence
Krystal Biotech, Inc. (KRYS) receives a BUY rating with 80% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $389.1M, net profit margin of 52.6%, and return on equity (ROE) of 16.8%, Krystal Biotech, Inc. demonstrates strong fundamentals in the Healthcare sector. Below is our complete KRYS stock analysis for 2026.

Is Krystal Biotech, Inc. (KRYS) a Good Investment?

Claude

Krystal Biotech exhibits exceptional financial strength with 52.6% net margins, 41.5% operating margins, and robust 188.9M free cash flow generation. The company maintains a fortress balance sheet with minimal debt (4.3M), substantial cash reserves (496.3M), and exceptional liquidity (9.95x current ratio), providing significant strategic flexibility. However, net income growth (129.7% YoY) significantly outpacing revenue growth (33.9%) requires validation of sustainability before higher conviction.

ChatGPT

Krystal Biotech shows standout fundamentals with 33.9% revenue growth, exceptional operating (41.5%) and net (52.6%) margins, strong ROE/ROA, and a 48.5% FCF margin. A cash-rich, near-debt-free balance sheet supports continued investment, with upside if revenue proves recurring rather than milestone-driven.

Why Buy Krystal Biotech, Inc. Stock? KRYS Key Strengths

Claude
  • + Fortress balance sheet with minimal leverage (0.00x debt/equity), 496.3M cash reserves, and exceptional liquidity ratios (9.95x current, 9.56x quick) providing substantial financial flexibility and downside protection
  • + Exceptional profitability metrics with 52.6% net margin and 41.5% operating margin demonstrating strong pricing power and operational efficiency
  • + Robust free cash flow generation of 188.9M with 48.5% FCF margin and low capital intensity (12.0M CapEx) indicating highly cash-generative business model
  • + Solid revenue growth of 33.9% YoY with net income surge of 129.7%, suggesting significant operating leverage and margin expansion
ChatGPT
  • + Exceptional profitability and cash generation (operating margin 41.5%, FCF margin 48.5%).
  • + Robust liquidity and minimal leverage (current ratio 9.95x; negligible debt).
  • + Healthy returns on capital (ROE 16.8%, ROA 15.4%).

KRYS Stock Risks: Krystal Biotech, Inc. Investment Risks

Claude
  • ! Net income growth (129.7% YoY) substantially exceeds revenue growth (33.9%), indicating potential one-time gains, accounting benefits, or unsustainable cost reductions that require validation of recurring nature
  • ! Gross margin data unavailable prevents assessment of underlying product profitability and true operational performance quality; unusually high net margin warrants scrutiny
  • ! Biotech sector inherent risks including regulatory approval delays, clinical trial failures, patent expiration, competitive pressures, and R&D project attrition could materially impact future revenue and margins
ChatGPT
  • ! Revenue durability and concentration risk typical of early commercial biotechs.
  • ! Potential non-recurring or milestone revenue inflating margins (gross margin N/A).
  • ! Pricing/reimbursement and regulatory/manufacturing execution could pressure growth.

Key Metrics to Watch

Claude
  • * Gross margin trend and composition - critical to understanding true profitability and sustainability of exceptional net margins
  • * Net income sustainability analysis - determine if 129.7% growth derived from operating leverage, one-time items, or recurring operations
  • * Revenue growth trajectory - monitor if 33.9% growth rate sustains, accelerates, or decelerates in subsequent reporting periods
ChatGPT
  • * Revenue mix: recurring product vs one-time/milestone.
  • * Operating margin sustainability (target >=35%).

Krystal Biotech, Inc. (KRYS) Financial Metrics & Key Ratios

Revenue
$389.1M
Net Income
$204.8M
EPS (Diluted)
$6.84
Free Cash Flow
$188.9M
Total Assets
$1.3B
Cash Position
$496.3M

💡 AI Analyst Insight

The 48.5% free cash flow margin provides substantial flexibility for dividends, buybacks, and strategic investments. Strong liquidity with a 9.95x current ratio provides a solid financial cushion.

KRYS Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin 41.5%
Net Margin 52.6%
ROE 16.8%
ROA 15.4%
FCF Margin 48.5%

KRYS vs Healthcare Sector: How Krystal Biotech, Inc. Compares

How Krystal Biotech, Inc. compares to Healthcare sector averages

Net Margin
KRYS 52.6%
vs
Sector Avg 12.0%
KRYS Sector
ROE
KRYS 16.8%
vs
Sector Avg 15.0%
KRYS Sector
Current Ratio
KRYS 10.0x
vs
Sector Avg 2.0x
KRYS Sector
Debt/Equity
KRYS 0.0x
vs
Sector Avg 0.6x
KRYS Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is Krystal Biotech, Inc. Stock Overvalued? KRYS Valuation Analysis 2026

Based on fundamental analysis, Krystal Biotech, Inc. appears fundamentally strong relative to the Healthcare sector in 2026.

Return on Equity
16.8%
Sector avg: 15%
Net Profit Margin
52.6%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

Krystal Biotech, Inc. Balance Sheet: KRYS Debt, Cash & Liquidity

Current Ratio
9.95x
Quick Ratio
9.56x
Debt/Equity
0.00x
Debt/Assets
8.6%
Interest Coverage
N/A
Long-term Debt
$4.3M

KRYS Revenue & Earnings Growth: 5-Year Financial Trend

KRYS 5-year financial data: Year 2023: Revenue $50.7M, Net Income -$69.6M, EPS $-3.13. Year 2024: Revenue $290.5M, Net Income -$140.0M, EPS $-5.49. Year 2025: Revenue $389.1M, Net Income $10.9M, EPS $0.39.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: Krystal Biotech, Inc.'s revenue has grown significantly by 668% over the 5-year period, indicating strong business expansion. The most recent EPS of $0.39 reflects profitable operations.

KRYS Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
48.5%
Free cash flow / Revenue

KRYS Quarterly Earnings & Performance

Quarterly financial performance data for Krystal Biotech, Inc. including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $83.8M $932.0K $0.91
Q2 2025 $70.3M $932.0K $0.53
Q1 2025 $45.3M $932.0K $0.03
Q3 2024 $8.6M $932.0K $0.08
Q2 2024 N/A $932.0K $0.53
Q1 2024 N/A $932.0K $0.03
Q3 2023 N/A $2.2M $0.08

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

Krystal Biotech, Inc. Dividends, Buybacks & Capital Allocation

Operating Cash Flow
$200.9M
Cash generated from operations
Capital Expenditures
$12.0M
Investment in assets
Dividends
None
No dividend program

KRYS SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for Krystal Biotech, Inc. (CIK: 0001711279)

📋 Recent SEC Filings

Date Form Document Action
Apr 3, 2026 DEF 14A krys-20260403.htm View →
Mar 6, 2026 4 xslF345X05/wk-form4_1772839386.xml View →
Mar 6, 2026 4 xslF345X05/wk-form4_1772839326.xml View →
Mar 3, 2026 4 xslF345X05/wk-form4_1772580832.xml View →
Mar 3, 2026 4 xslF345X05/wk-form4_1772580780.xml View →

Frequently Asked Questions about KRYS

What is the AI rating for KRYS?

Krystal Biotech, Inc. (KRYS) has a Combined AI Rating of BUY from Claude (STRONG BUY) and ChatGPT (BUY) with 80% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are KRYS's key strengths?

Claude: Fortress balance sheet with minimal leverage (0.00x debt/equity), 496.3M cash reserves, and exceptional liquidity ratios (9.95x current, 9.56x quick) providing substantial financial flexibility and downside protection. Exceptional profitability metrics with 52.6% net margin and 41.5% operating margin demonstrating strong pricing power and operational efficiency. ChatGPT: Exceptional profitability and cash generation (operating margin 41.5%, FCF margin 48.5%).. Robust liquidity and minimal leverage (current ratio 9.95x; negligible debt)..

What are the risks of investing in KRYS?

Claude: Net income growth (129.7% YoY) substantially exceeds revenue growth (33.9%), indicating potential one-time gains, accounting benefits, or unsustainable cost reductions that require validation of recurring nature. Gross margin data unavailable prevents assessment of underlying product profitability and true operational performance quality; unusually high net margin warrants scrutiny. ChatGPT: Revenue durability and concentration risk typical of early commercial biotechs.. Potential non-recurring or milestone revenue inflating margins (gross margin N/A)..

What is KRYS's revenue and growth?

Krystal Biotech, Inc. reported revenue of $389.1M.

Does KRYS pay dividends?

Krystal Biotech, Inc. does not currently pay dividends.

Where can I find KRYS SEC filings?

Official SEC filings for Krystal Biotech, Inc. (CIK: 0001711279) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is KRYS's EPS?

Krystal Biotech, Inc. has a diluted EPS of $6.84.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is KRYS a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, Krystal Biotech, Inc. has a BUY rating with 80% confidence. The AI analysis suggests favorable fundamentals based on SEC filings. This is not investment advice.

Is KRYS stock overvalued or undervalued?

Valuation metrics for KRYS: ROE of 16.8% (sector avg: 15%), net margin of 52.6% (sector avg: 12%). Higher ROE suggests strong returns relative to peers.

Should I buy KRYS stock in 2026?

Our dual AI analysis gives Krystal Biotech, Inc. a combined BUY rating for 2026. Revenue is data pending, with profitability above sector average. Always conduct your own research.

What is KRYS's free cash flow?

Krystal Biotech, Inc.'s operating cash flow is $200.9M, with capital expenditures of $12.0M. FCF margin is 48.5%.

How does KRYS compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin 52.6% (avg: 12%), ROE 16.8% (avg: 15%), current ratio 9.95 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Apr 12, 2026 | Data as of: 2025-12-31 | Powered by Claude AI