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CRISPR Therapeutics AG (CRSP) Stock Fundamental Analysis & AI Rating 2026

CRSP Nasdaq Biological Products, (No Diagnostic Substances) V8 CIK: 0001674416
Updated This Month • Analysis: Mar 23, 2026 • SEC Data: 2025-12-31
Combined AI Rating
SELL
82% Confidence
NEUTRAL
STRONG SELL
92% Conf
HOLD
73% Conf

📊 CRSP Key Takeaways

Revenue: $3.5M
Net Margin: -16,569.8%
Free Cash Flow: $-345.9M
Current Ratio: 13.32x
Debt/Equity: 0.00x
EPS: $-6.47
AI Rating: STRONG SELL with 92% confidence
CRISPR Therapeutics AG (CRSP) receives a SELL rating with 82% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $3.5M, net profit margin of -16,569.8%, and return on equity (ROE) of -30.3%, CRISPR Therapeutics AG demonstrates mixed fundamentals in the Healthcare sector. Below is our complete CRSP stock analysis for 2026.

Is CRISPR Therapeutics AG (CRSP) a Good Investment?

Claude

CRSP is a pre-commercial stage biotech company burning significant cash with minimal revenue, posting operating losses exceeding $664M and free cash flow of -$346M. While the company maintains a strong balance sheet with $347.6M in cash and minimal debt, the 90.6% revenue collapse and massive operating losses indicate the business is not yet generating sustainable economic value. At current cash burn rates, the company has limited runway before requiring additional financing or demonstrating meaningful clinical/commercial progress.

ChatGPT

CRISPR Therapeutics' fundamentals show a classic development-stage biotech profile: minimal and highly volatile revenue, very large operating losses, and deeply negative free cash flow. The main offset is an exceptionally strong balance sheet, with substantial cash, no meaningful long-term debt, and very high liquidity, which gives the company time to fund R&D and absorb commercialization delays. Fundamental upside depends less on current earnings quality and more on whether revenue becomes durable while cash burn narrows.

Why Buy CRISPR Therapeutics AG Stock? CRSP Key Strengths

Claude
  • + Strong balance sheet with $1.9B stockholders equity and no meaningful long-term debt
  • + Adequate liquidity with $347.6M cash and 13.32x current ratio
  • + Significant insider activity with 13 Form 4 filings indicating management engagement
ChatGPT
  • + Very strong liquidity profile, with cash of $347.56M and current and quick ratios of 13.32x
  • + Debt-free balance sheet and $1.92B equity base provide financial flexibility
  • + Large asset base relative to liabilities reduces near-term solvency pressure

CRSP Stock Risks: CRISPR Therapeutics AG Investment Risks

Claude
  • ! Severe cash burn of $345M in operating cash flow with negative free cash flow of -$346M
  • ! Revenue collapsed 90.6% YoY to just $3.5M, indicating loss of major revenue source or milestone delays
  • ! Operating losses of $664.6M and net losses of $581.6M demonstrate pre-commercial stage business model with no clear path to profitability
ChatGPT
  • ! Revenue fell 90.6% year over year, indicating weak revenue durability and poor growth quality
  • ! Operating loss of $664.57M and net loss of $581.60M reflect an unsustainable profitability profile
  • ! Negative operating cash flow of $345.01M shows continued heavy cash consumption that could pressure future funding needs

Key Metrics to Watch

Claude
  • * Quarterly cash burn rate and cash runway extension
  • * Clinical trial progress and regulatory milestones for pipeline programs
  • * Revenue stabilization and growth from existing or new partnerships/programs
ChatGPT
  • * Quarterly revenue consistency and commercialization-related revenue growth
  • * Operating cash burn relative to cash and equivalents

CRISPR Therapeutics AG (CRSP) Financial Metrics & Key Ratios

Revenue
$3.5M
Net Income
$-581.6M
EPS (Diluted)
$-6.47
Free Cash Flow
$-345.9M
Total Assets
$2.3B
Cash Position
$347.6M

💡 AI Analyst Insight

Strong liquidity with a 13.32x current ratio provides a solid financial cushion.

CRSP Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -18,933.6%
Net Margin -16,569.8%
ROE -30.3%
ROA -25.7%
FCF Margin -9,855.5%

CRSP vs Healthcare Sector: How CRISPR Therapeutics AG Compares

How CRISPR Therapeutics AG compares to Healthcare sector averages

Net Margin
CRSP -16,569.8%
vs
Sector Avg 12.0%
CRSP Sector
ROE
CRSP -30.3%
vs
Sector Avg 15.0%
CRSP Sector
Current Ratio
CRSP 13.3x
vs
Sector Avg 2.0x
CRSP Sector
Debt/Equity
CRSP 0.0x
vs
Sector Avg 0.6x
CRSP Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is CRISPR Therapeutics AG Stock Overvalued? CRSP Valuation Analysis 2026

Based on fundamental analysis, CRISPR Therapeutics AG has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-30.3%
Sector avg: 15%
Net Profit Margin
-16,569.8%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.00x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

CRISPR Therapeutics AG Balance Sheet: CRSP Debt, Cash & Liquidity

Current Ratio
13.32x
Quick Ratio
13.32x
Debt/Equity
0.00x
Debt/Assets
15.2%
Interest Coverage
N/A
Long-term Debt
N/A

CRSP Revenue & Earnings Growth: 5-Year Financial Trend

CRSP 5-year financial data: Year 2021: Revenue $915.0M, Net Income $66.9M, EPS $1.17. Year 2022: Revenue $915.0M, Net Income -$348.9M, EPS $-5.29. Year 2023: Revenue $915.0M, Net Income $377.7M, EPS $4.70. Year 2024: Revenue $371.2M, Net Income -$650.2M, EPS $-8.36. Year 2025: Revenue $371.2M, Net Income -$153.6M, EPS $-1.94.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: CRISPR Therapeutics AG's revenue has declined by 59% over the 5-year period, indicating business contraction. The most recent EPS of $-1.94 indicates the company is currently unprofitable.

CRSP Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-9,855.5%
Free cash flow / Revenue

CRSP Quarterly Earnings & Performance

Quarterly financial performance data for CRISPR Therapeutics AG including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 $602.0K -$85.9M $-1.01
Q2 2025 $517.0K -$116.6M $-1.49
Q1 2025 $504.0K -$116.6M $-1.43
Q3 2024 N/A -$53.1M $-1.01
Q2 2024 $517.0K -$53.1M $-0.98
Q1 2024 $504.0K -$53.1M $-0.67
Q3 2023 N/A -$53.1M $-1.41
Q2 2023 $158.0K -$53.1M $-0.98

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

CRISPR Therapeutics AG Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$345.0M
Cash generated from operations
Stock Buybacks
$57.0K
Shares repurchased (TTM)
Capital Expenditures
$914.0K
Investment in assets
Dividends
None
No dividend program

CRSP SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for CRISPR Therapeutics AG (CIK: 0001674416)

📋 Recent SEC Filings

Date Form Document Action
Mar 24, 2026 4 xslF345X06/ownership.xml View →
Mar 24, 2026 4 xslF345X06/ownership.xml View →
Mar 24, 2026 4 xslF345X06/ownership.xml View →
Mar 24, 2026 4 xslF345X06/ownership.xml View →
Mar 17, 2026 4 xslF345X05/ownership.xml View →

Frequently Asked Questions about CRSP

What is the AI rating for CRSP?

CRISPR Therapeutics AG (CRSP) has a Combined AI Rating of SELL from Claude (STRONG SELL) and ChatGPT (HOLD) with 82% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are CRSP's key strengths?

Claude: Strong balance sheet with $1.9B stockholders equity and no meaningful long-term debt. Adequate liquidity with $347.6M cash and 13.32x current ratio. ChatGPT: Very strong liquidity profile, with cash of $347.56M and current and quick ratios of 13.32x. Debt-free balance sheet and $1.92B equity base provide financial flexibility.

What are the risks of investing in CRSP?

Claude: Severe cash burn of $345M in operating cash flow with negative free cash flow of -$346M. Revenue collapsed 90.6% YoY to just $3.5M, indicating loss of major revenue source or milestone delays. ChatGPT: Revenue fell 90.6% year over year, indicating weak revenue durability and poor growth quality. Operating loss of $664.57M and net loss of $581.60M reflect an unsustainable profitability profile.

What is CRSP's revenue and growth?

CRISPR Therapeutics AG reported revenue of $3.5M.

Does CRSP pay dividends?

CRISPR Therapeutics AG does not currently pay dividends.

Where can I find CRSP SEC filings?

Official SEC filings for CRISPR Therapeutics AG (CIK: 0001674416) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is CRSP's EPS?

CRISPR Therapeutics AG has a diluted EPS of $-6.47.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is CRSP a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, CRISPR Therapeutics AG has a SELL rating with 82% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is CRSP stock overvalued or undervalued?

Valuation metrics for CRSP: ROE of -30.3% (sector avg: 15%), net margin of -16,569.8% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy CRSP stock in 2026?

Our dual AI analysis gives CRISPR Therapeutics AG a combined SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is CRSP's free cash flow?

CRISPR Therapeutics AG's operating cash flow is $-345.0M, with capital expenditures of $914.0K. FCF margin is -9,855.5%.

How does CRSP compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -16,569.8% (avg: 12%), ROE -30.3% (avg: 15%), current ratio 13.32 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 23, 2026 | Data as of: 2025-12-31 | Powered by Claude AI