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aTYR PHARMA INC (ATYR) Stock Fundamental Analysis & AI Rating 2026

ATYR Nasdaq Biological Products, (No Diagnostic Substances) DE CIK: 0001339970
Updated This Month • Analysis: Mar 20, 2026 • SEC Data: 2025-12-31
Combined AI Rating
STRONG SELL
90% Confidence
STRONG AGREEMENT
STRONG SELL
92% Conf
STRONG SELL
87% Conf

📊 ATYR Key Takeaways

Revenue: $190.0K
Net Margin: -39,009.5%
Free Cash Flow: $-62.1M
Current Ratio: 5.30x
Debt/Equity: 0.04x
EPS: $-0.80
AI Rating: STRONG SELL with 92% confidence
aTYR PHARMA INC (ATYR) receives a STRONG SELL rating with 90% confidence from our AI fundamental analysis based on SEC 10-K filings. With revenue of $190.0K, net profit margin of -39,009.5%, and return on equity (ROE) of -109.8%, aTYR PHARMA INC demonstrates mixed fundamentals in the Healthcare sector. Below is our complete ATYR stock analysis for 2026.

Is aTYR PHARMA INC (ATYR) a Good Investment?

Claude

aTYR Pharma is a pre-revenue stage biotech company with minimal commercialization progress and severe financial deterioration. The company is burning cash at an unsustainable rate ($62M operating cash outflow) while generating only $190K in revenue, indicating clinical-stage operations with no meaningful product commercialization. At current burn rates, the company has limited runway and faces imminent capital requirements.

ChatGPT

aTyr Pharma's fundamentals are very weak: revenue is negligible and declining, while operating and net losses remain massive relative to the size of the business. Although leverage is low and current liquidity ratios look strong, the combination of just $10.74M in cash against roughly $62.06M of annual free cash outflow points to significant funding risk and poor growth quality.

Why Buy aTYR PHARMA INC Stock? ATYR Key Strengths

Claude
  • + Strong liquidity position with 5.3x current ratio providing near-term operational flexibility
  • + Conservative leverage with 0.04x debt-to-equity ratio indicating low financial risk from debt obligations
  • + Modest stockholders' equity base of $67.5M provides some capital cushion for continued R&D investment
ChatGPT
  • + Low balance-sheet leverage with debt/equity of 0.04x
  • + Current and quick ratios of 5.30x indicate limited near-term liability pressure
  • + Positive YoY EPS improvement suggests some cost discipline at the per-share level

ATYR Stock Risks: aTYR PHARMA INC Investment Risks

Claude
  • ! Extreme cash burn of $62M annually with only $10.7M cash on hand, providing less than 2 months of runway at current burn rates
  • ! Negligible revenue of $190K indicates no viable commercial products and complete dependence on capital markets for funding
  • ! Massive net losses of $74.1M representing -39,009.5% net margin, demonstrating fundamental unprofitability and inability to achieve commercialization milestones
  • ! Operating cash flow deficit of $62M annually with negative free cash flow margin of -32,664.7% indicates unsustainable business model
  • ! High insider trading activity (6 Form 4 filings in 90 days) may signal management concern about company trajectory
ChatGPT
  • ! Revenue base is extremely small at $190K and declined 19.1% YoY
  • ! Profitability is deeply negative with net loss of $74.12M and net margin around -39009.5%
  • ! Cash burn is severe, with operating cash flow of -$61.99M versus only $10.74M of cash on hand

Key Metrics to Watch

Claude
  • * Cash burn rate and cash runway remaining before next financing requirement
  • * Revenue growth trajectory and progress toward commercial viability
  • * R&D spending efficiency and clinical trial advancement status
  • * Quarterly cash position and liquidity levels
  • * Insider trading patterns and management confidence indicators
ChatGPT
  • * Quarterly operating cash burn relative to cash and equivalents
  • * Clinical/commercial revenue traction and any sustained reduction in operating loss

aTYR PHARMA INC (ATYR) Financial Metrics & Key Ratios

Revenue
$190.0K
Net Income
$-74.1M
EPS (Diluted)
$-0.80
Free Cash Flow
$-62.1M
Total Assets
$93.0M
Cash Position
$10.7M

💡 AI Analyst Insight

Strong liquidity with a 5.30x current ratio provides a solid financial cushion.

ATYR Profit Margin, ROE & Profitability Analysis

Gross Margin N/A
Operating Margin -40,856.3%
Net Margin -39,009.5%
ROE -109.8%
ROA -79.7%
FCF Margin -32,664.7%

ATYR vs Healthcare Sector: How aTYR PHARMA INC Compares

How aTYR PHARMA INC compares to Healthcare sector averages

Net Margin
ATYR -39,009.5%
vs
Sector Avg 12.0%
ATYR Sector
ROE
ATYR -109.8%
vs
Sector Avg 15.0%
ATYR Sector
Current Ratio
ATYR 5.3x
vs
Sector Avg 2.0x
ATYR Sector
Debt/Equity
ATYR 0.0x
vs
Sector Avg 0.6x
ATYR Sector

Sector benchmarks are approximate industry averages. Actual sector performance may vary.

Is aTYR PHARMA INC Stock Overvalued? ATYR Valuation Analysis 2026

Based on fundamental analysis, aTYR PHARMA INC has mixed fundamental signals relative to the Healthcare sector in 2026.

Return on Equity
-109.8%
Sector avg: 15%
Net Profit Margin
-39,009.5%
Sector avg: 12%
Revenue Growth
N/A
Year-over-year
Debt/Equity
0.04x
Sector avg: 0.6x

Note: This is a fundamental analysis based on SEC filings. For P/E ratio, price targets, and market-based valuation, consult financial data providers. This is not investment advice.

aTYR PHARMA INC Balance Sheet: ATYR Debt, Cash & Liquidity

Current Ratio
5.30x
Quick Ratio
5.30x
Debt/Equity
0.04x
Debt/Assets
0.0%
Interest Coverage
N/A
Long-term Debt
$2.7M

ATYR Revenue & Earnings Growth: 5-Year Financial Trend

ATYR 5-year financial data: Year 2021: Revenue $10.5M, Net Income -$23.6M, EPS N/A. Year 2022: Revenue $10.5M, Net Income -$16.2M, EPS $-1.77. Year 2023: Revenue $10.4M, Net Income -$33.8M, EPS $-1.77. Year 2024: Revenue $10.4M, Net Income -$45.3M, EPS $-1.60. Year 2025: Revenue $353.0K, Net Income -$50.4M, EPS $-0.94.
Revenue
Net Income
EPS (right axis)

5-Year Trend Summary: aTYR PHARMA INC's revenue has declined by 97% over the 5-year period, indicating business contraction. The most recent EPS of $-0.94 indicates the company is currently unprofitable.

ATYR Revenue Growth, EPS Growth & YoY Performance

Revenue Growth
N/A
Year-over-year
Net Income Growth
N/A
Year-over-year
EPS Growth
N/A
Earnings per share
FCF Margin
-32,664.7%
Free cash flow / Revenue

ATYR Quarterly Earnings & Performance

Quarterly financial performance data for aTYR PHARMA INC including revenue, net income, and earnings per share.
Quarter Revenue Net Income EPS
Q3 2025 N/A -$17.3M $-0.23
Q2 2025 N/A -$16.3M $-0.22
Q1 2025 N/A -$14.9M $-0.17
Q3 2024 N/A -$11.3M $-0.20
Q2 2024 N/A -$12.3M $-0.22
Q1 2024 N/A -$12.0M $-0.23
Q3 2023 N/A -$11.3M $-0.20
Q3 2021 $148.0K -$6.6M N/A

Data sourced from SEC EDGAR 10-Q quarterly filings. Figures may represent quarterly or cumulative values.

aTYR PHARMA INC Dividends, Buybacks & Capital Allocation

Operating Cash Flow
-$62.0M
Cash generated from operations
Capital Expenditures
$77.0K
Investment in assets
Dividends
None
No dividend program

ATYR SEC Filings: Latest 10-K & 10-Q Analysis

Access official SEC EDGAR filings for aTYR PHARMA INC (CIK: 0001339970)

📋 Recent SEC Filings

Date Form Document Action
Mar 26, 2026 DEF 14A atyr-20260326.htm View →
Mar 5, 2026 10-K atyr-20251231.htm View →
Mar 5, 2026 8-K atyr-20260305.htm View →
Feb 4, 2026 4 xslF345X05/ownership.xml View →
Feb 4, 2026 4 xslF345X05/ownership.xml View →

Frequently Asked Questions about ATYR

What is the AI rating for ATYR?

aTYR PHARMA INC (ATYR) has a Combined AI Rating of STRONG SELL from Claude (STRONG SELL) and ChatGPT (STRONG SELL) with 90% combined confidence, based on fundamental analysis of SEC EDGAR filings.

What are ATYR's key strengths?

Claude: Strong liquidity position with 5.3x current ratio providing near-term operational flexibility. Conservative leverage with 0.04x debt-to-equity ratio indicating low financial risk from debt obligations. ChatGPT: Low balance-sheet leverage with debt/equity of 0.04x. Current and quick ratios of 5.30x indicate limited near-term liability pressure.

What are the risks of investing in ATYR?

Claude: Extreme cash burn of $62M annually with only $10.7M cash on hand, providing less than 2 months of runway at current burn rates. Negligible revenue of $190K indicates no viable commercial products and complete dependence on capital markets for funding. ChatGPT: Revenue base is extremely small at $190K and declined 19.1% YoY. Profitability is deeply negative with net loss of $74.12M and net margin around -39009.5%.

What is ATYR's revenue and growth?

aTYR PHARMA INC reported revenue of $190.0K.

Does ATYR pay dividends?

aTYR PHARMA INC does not currently pay dividends.

Where can I find ATYR SEC filings?

Official SEC filings for aTYR PHARMA INC (CIK: 0001339970) including 10-K, 10-Q, and 8-K reports are available on SEC EDGAR.

What is ATYR's EPS?

aTYR PHARMA INC has a diluted EPS of $-0.80.

How is the AI analysis conducted?

Two independent AI systems — Claude (Anthropic) and ChatGPT (OpenAI) — analyze SEC EDGAR filings including 10-K annual reports and 10-Q quarterly reports. Each AI evaluates financial health, profitability ratios, balance sheet strength, and growth metrics. The combined rating reflects both perspectives for balanced insights.

Is ATYR a good stock to buy right now?

Based on our AI fundamental analysis in April 2026, aTYR PHARMA INC has a STRONG SELL rating with 90% confidence. Review the strengths and risks sections above before making a decision. This is not investment advice.

Is ATYR stock overvalued or undervalued?

Valuation metrics for ATYR: ROE of -109.8% (sector avg: 15%), net margin of -39,009.5% (sector avg: 12%). Compare these metrics with sector averages to assess valuation.

Should I buy ATYR stock in 2026?

Our dual AI analysis gives aTYR PHARMA INC a combined STRONG SELL rating for 2026. Revenue is data pending, with profitability at or below sector average. Always conduct your own research.

What is ATYR's free cash flow?

aTYR PHARMA INC's operating cash flow is $-62.0M, with capital expenditures of $77.0K. FCF margin is -32,664.7%.

How does ATYR compare to other Healthcare stocks?

Vs Healthcare sector averages: Net margin -39,009.5% (avg: 12%), ROE -109.8% (avg: 15%), current ratio 5.30 (avg: 2).

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Disclaimer: This analysis is generated by Claude AI (Anthropic) and ChatGPT (OpenAI) based on publicly available SEC EDGAR filings. It does not include stock price data and should not be considered financial advice. All fundamental data is sourced from SEC public domain filings. Always conduct your own research and consult with a qualified financial advisor before making investment decisions.
Data Source: SEC EDGAR | Analysis Date: Mar 20, 2026 | Data as of: 2025-12-31 | Powered by Claude AI